麦粒灸治疗抑郁症的临床研究进展与展望OA

Depression is a commonly seen psychiatric disorder in clinical practice,which greatly jeopardizes the mental and physical health of pa-tients,seriously affecting their quality of life.Wheat grain moxibustion,as one form of ancient moxibustion therapy,has gradually been applied in the prevention and treatment of depression.It has precise positioning,strong thermal penetration,short duration,and quick effects,which can greatly stimulate the body's yang energy.Wheat grain moxibustion in the treatment of depression has been shown to upregulate the expression of brain-derived neurotrophic factor(BDNF)protein in the human body,repair and regenerate hippocampal neurons,inhibit inflammatory responses,and acti-vate the ERK-Nrf2 signaling pathway.Its clinical efficacy is affirmed,but further standardization of the operating procedures for wheat grain moxi-bustion and the establishment of uniform evaluation indicators for therapeutic effects are needed in clinical practice.This article provides a compre-hensive review of the theoretical mechanisms of wheat grain moxibustion in the treatment of depression from the perspectives of both Chinese and Western medicine,the etiology of depression in Chinese and Western medicine,the use of wheat grain moxibustion as a standalone therapy,and the combination of wheat grain moxibustion with other treatment modalities.