大气NO2短期暴露与不同体重年轻个体凝血功能相关指标的关联及气温的修饰作用OA北大核心CSTPCD

[Background]Nitrogen dioxide(NO2)is one of the main air pollutants,and though China's NO2 pollution has been improving year by year,it maintains at a high level,threatening the health of the population. [Objective]To investigate the effect of short-term exposure to atmospheric NO2 on the coagula-tion indexes in obese and normal-weight young individuals and potential modification effect of temperature. [Methods]Based on a parallel control panel study design,this study recruited 53 normal-weight and 44 obese young individuals.Three prospective follow-ups were conducted.Air pollution data were obtained from the fixed monitoring station closest to the participant's residences,and personal air pollution exposure was simulated based on time-activity log and infiltration factor for the week before every follow-up.Temperature was collected from China Meteorological Data Service Center.Venous blood samples were taken to measure platelet(PLT)count,mean platelet volume(MPV),soluble CD40 ligand(sCD40L),soluble P-selectin(sP-selectin),platelet aggregation rate(PAgT),and plasminogen activator inhibitor type-1(PAI-1)during every follow-up.A linear mixed-effect model was used to assess the association between short-term atmospheric NO2 exposure and the coagulation indexes of weight grouped young individuals,and a stratified analysis was used to explore potential modification effect of temperature. [Results]The median[interquartile range(IQR)]of personal atmospheric NO2 exposure concentrations was 21.47(8.01)μg·m-3.Short-term exposure to atmospheric NO2 was significantly associated the increase of sCD40L and PAgT in the obese individuals,while the most significant association appeared at 5 d lag,and for each IQR increase in the average sliding exposure concentration of atmospheric NO2 with a 5 d lag,sCD40L increased by 27.4%(95%CI:4.2%,56.6%)and PAgT increased by 37.5%(95%CI:12.2%,68.6%);short-term exposure to atmospheric NO2 was significantly associated with the decrease of PLT and PAgT in the normal-weight individuals,while the most sig-nificant association appeared at 5 d lag or 7 d lag,and for each IQR increase in the average sliding exposure concentration of atmospheric NO2 with a 5 d lag,PLT decreased by 11.8%(95%CI:-17.8%,-5.3%),and for each IQR increase in the average sliding exposure concentration of atmospheric NO2 with a 7 d lag,PAgT decreased by 16.8%(95%CI:-30.6%,-0.4%).We didn't find statistically significant association of short-term exposure to atmospheric NO2 with PLT in the obese individuals or sCD40L in the normal-weight individuals,nor statistically significant association between short-term exposure to atmospheric NO2 and PAI-1,MPV,and sP-selectin in different weight grouped in-dividuals.The stratified analysis found that short-term exposure to atmospheric NO2 was significantly associated with PAgT in the normal-weight individuals,or with PLT,sCD40L,and sP-selectin in the obese individuals only at high temperature. [Conclusions]Short-term exposure to atmospheric NO2 has adverse effects on the coagulation indexes of different weight grouped young individuals,and the obese individuals are more sensitive to it than the normal-weight individuals.High temperature can enhance the adverse health effect of short-term exposure to atmospheric NO2.