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New advances of adiponectin in regulating obesity and related metabolic syndromesOA

New advances of adiponectin in regulating obesity and related metabolic syndromes

英文摘要

Obesity and related metabolic syndromes have been recognized as important disease risks,in which the role of adipokines cannot be ignored.Adiponectin(ADP)is one of the key adipokines with various beneficial effects,including improving glucose and lipid metabolism,enhancing insulin sensitivity,reducing oxidative stress and inflammation,promoting ceramides degradation,and stimulating adipose tissue vascularity.Based on those,it can serve as a positive regulator in many metabolic syndromes,such as type 2 diabetes(T2D),cardiovascular diseases,non-alcoholic fatty liver disease(NAFLD),sarcopenia,neurodegenerative diseases,and certain cancers.Therefore,a promising therapeutic approach for treating various metabolic diseases may involve elevating ADP levels or activating ADP receptors.The modulation of ADP genes,multimerization,and secretion covers the main processes of ADP generation,providing a comprehensive orientation for the development of more appropriate therapeutic strategies.In order to have a deeper understanding of ADP,this paper will provide an all-encompassing review of ADP.

Yanqi Han;Yanfang Yang;Qianwen Sun;Wei Chen;Yue Gao;Jun Ye;Yanmin Chen;Tingting Wang;Lili Gao;Yuling Liu

State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences &Peking Union Medical College,Beijing,100050,China||Beijing Key Laboratory of Drug Delivery Technology and Novel Formulation,Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing,100050,China

AdiponectinObesityMetabolic syndromeRegulation

《药物分析学报(英文)》 2024 (005)

623-638 / 16

This work was supported by the grants from the CAMS Inno-vation Fund for Medical Sciences(CIFMS)(Grant No.:2021-I2M-1-026)and the Beijing Natural Science Foundation of China(Grant Nos.:7212155 and 7162135).

10.1016/j.jpha.2023.12.003

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