中国食品添加剂2024，Vol.35Issue(8)：57-63,7.DOI:10.19804/j.issn1006-2513.2024.8.008
表儿茶素没食子酸酯对免疫低下小鼠免疫功能的调节作用
Modulatory effect of epigallocatechin gallate on immune function in immunocompromised mice
摘要
Abstract
To study the effect of epigallocatechin gallate(EGCG)on immune function in immunocompromised mice.An immunocompromised mouse model was constructed using cyclophosphamide,and the effects of EGCG on the immune organ index and splenic histopathological changes in immunocompromised mice were determined,and the expression levels of the immune cell nuclear transcription factors PAX5 and GATA3 as well as the expression levels of the key molecules of the NFκB,AKT,and MAPK signaling pathways were detected.The results showed that the spleen index(1.95 g/kg)and thymus index(0.73 g/kg)of EGCG-intervened mice increased significantly(P＜0.05)compared with those of the model group(1.43,0.47 g/kg),and EGCG improved the spleen mass/index of immunocompromised mice;the sectioning results showed that EGCG was able to alleviate the immune-compromised mice's spleen injury;partially restored the expression of PAX5 in B cells and GATA3 mRNA in T cells(P＜0.05);and up-regulated the phosphorylation levels of NFκB signaling pathway protein P65,AKT signaling pathway protein AKT,and MAPK signaling pathway protein P38 in the EGCG group compared with the model group(P＜0.05).In conclusion,EGCG had a certain promotion as well as repairing effect on the development of immune cells,and could enhance the immune function of immunocompromised mice.关键词
表儿茶素没食子酸酯/环磷酰胺/淋巴细胞/免疫功能Key words
epigallocatechin gallate/cyclophosphamide/lymphocytes/immune function分类
轻工纺织引用本文复制引用
夏雯雯,魏志新,郑诗琼,董晓语,邢俊俏,徐成,龚业莉..表儿茶素没食子酸酯对免疫低下小鼠免疫功能的调节作用[J].中国食品添加剂,2024,35(8):57-63,7.基金项目
国家重点研发计划(2020YFA0907400) （2020YFA0907400）
武汉科技局科研启动基金(2022020801010368) （2022020801010368）
江汉大学校级自然科学基金项目(2021yb135) （2021yb135）
江汉大学科研启动基金项目(06110001) （06110001）
