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人乳头瘤病毒所致感染的防控OA北大核心CSTPCD

The prevention and control of human papilloma-virus infection

中文摘要英文摘要

人乳头瘤病毒(human papillomavirus,HPV)所致感染是女性常见的性传播感染,低危型HPV感染可导致尖锐湿疣,高危型HPV持续感染可引起子宫颈癌前病变及子宫颈癌等疾病,严重威胁女性健康.近年来,我国HPV感染率及子宫颈癌发病率逐年升高,并呈年轻化趋势,因此应积极预防HPV感染以降低子宫颈癌以及其他HPV相关疾病及肿瘤的风险.针对HPV感染所致疾病的预防措施包括:(1)以健康教育及HPV疫苗接种为主要措施的一级预防.(2)以定期子宫颈癌筛查及癌前病变的早诊早治为主要措施的二级预防.(3)对子宫颈浸润癌进行诊治的三级预防.目前大量数据证明了 HPV疫苗在降低HPV感染所致疾病发病率方面的作用,而对于适龄女性开展适宜的子宫颈癌筛查并及时干预也能够降低子宫颈癌的发生风险和死亡率,建议将适龄女性的HPV疫苗接种及定期子宫颈癌筛查结合起来,最大限度降低HPV感染相关疾病风险,尽早实现世界卫生组织(WHO)消除子宫颈癌的宏伟目标.

Infection caused by human papillomavirus(HPV)is a common sexually transmitted infection among women,low-risk HPV infection can lead to condyloma acuminatum,and persistent high-risk HPV infection can cause cervical precancerous lesions and cervical cancer,which seriously threatens women's health.In recent years,the infection rate of HPV and the incidence of cervical cancer in China have in-creased year by year,and patients are becoming younger,so we should actively prevent HPV infection to reduce the risk of cervical cancer and other HPV-related diseases and tumors.Preventive measures against diseases caused by HPV infection include:primary prevention with health education and HPV vaccination as the main measures;Secondary preven-tion with regular cervical cancer screening and early diagnosis and treatment of precancerous lesions as the main measures;Tertiary prevention for diagnosis and treatment of invasive carcinoma of cervix.At present,a large number of data have proved the role of HPV vaccine in reducing the incidence of diseases caused by HPV infection.Appropriate cervical cancer screening and timely intervention for appropriate age women can also reduce the risk and mortality of cer-vical cancer.It is suggested to combine HPV vacci-nation with regular cervical cancer screening for ap-propriate age women to minimize the risk of diseases related to HPV infection and realize the grand goal of WHO to eliminate cervical cancer as soon as possible.

米兰;毕蕙

北京大学第一医院妇产科,北京 100034

临床医学

人乳头瘤病毒尖锐湿疣子宫颈癌前病变子宫颈癌人乳头瘤病毒疫苗筛查

human papillomaviruscondyloma acum-inatacervical precancerous lesionscervical cancerHPV vaccinescreening

《中国实用妇科与产科杂志》 2024 (007)

687-692 / 6

国家自然科学基金(62273326)

10.19538/j.fk2024070105

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