现代食品科技2024，Vol.40Issue(7)：35-43,9.DOI:10.13982/j.mfst.1673-9078.2024.7.0795
益生菌发酵番茄汁对酒精中毒小鼠的解酒护肝作用
Effects of Probiotic Fermented Tomato Juice on Antialcoholism and Liver Protection in Alcohol-intoxicated Mice
摘要
Abstract
The efficacy and mechanisms of probiotic fermented tomato juice(PFTJ)in mitigating the impact of alcohol,and its ability to protect the liver were examined.The effects of different doses of PFTJ on the time taken by mice to sober up and on the activity of alcohol dehydrogenase(ADH)in mice were analyzed using mouse models of acute alcohol intoxication.In the meantime,models of chronic alcohol intoxication were established to investigate the effects of PFTJ on the liver function indicators and lipid metabolism indicators in serum as well as the antioxidant indicators in liver tissue of mice.In addition,histopathological analysis was conducted.The results showed that PFTJ significantly shortened the time taken by mice to sober up and improved ADH activity in acute alcohol intoxication models.Compared with those of the model group,the activities of aspartate transaminase(AST)and alanine aminotransferase(ALT)decreaseds by 24.87%and 26.65%,respectively(P<0.05),and the levels of triglyceride(TG)and total cholesterol(TC)reduced to 0.58 mmol/L and 1.21 mmol/L,respectively,in the high-dose group(15 mL/kg).The activities of catalase(CAT)and superoxide dismutase(SOD)in liver tissue increased by 17.05%and 22.91%,respectively(P<0.05),while the content of malondialdehyde(MDA)declined by 34.69%(P<0.05).The administration of 15 mL/kg PFTJ remarkably relieved liver cell swelling and steatosis in the mouse models.In conclusion,PFTJ can increase ADH activity to accelerate ethanol metabolism and enhance activities of antioxidant enzymes to eliminate free radicals in the liver and restore lipid metabolism.Therefore,PFTJ has the potential to become a new functional food for sobering up and liver protection.关键词
益生菌发酵番茄汁/解酒/护肝/小鼠Key words
probiotic fermented tomato juice/sobering up/liver protection/mice引用本文复制引用
韩紫薇,赵斗,马自强,仇燕..益生菌发酵番茄汁对酒精中毒小鼠的解酒护肝作用[J].现代食品科技,2024,40(7):35-43,9.基金项目
新疆生产建设兵团中央引导地方科技发展资金项目(2023) （2023）
河北省重点研发计划项目(22322801D) （22322801D）
