海南医学院学报2024，Vol.30Issue(16)：1230-1235,6.DOI:10.13210/j.cnki.jhmu.20240521.001
原发性失眠患者奖赏网络关键核团在静息态fMRI功能连接的改变
Altered functional connectivity of key nuclei of the reward network in resting-state fMRI in patients with primary insomnia
摘要
Abstract
Objective:To observe the alterations of brain functional connectivity in the Ventral ttegmental area(VTA)and the Nucleus accumbens(NAcc)in the reward network area of primary patients using functional magnetic resonance imaging(fM-RI).Methods:Twenty-eight patients with primary insomnia were compared with 26 healthy controls,and the relationship between altered functional connectivity in the Ventral Ttegmental Area(VTA)and the Nucleus Accumbens(NAcc)and mood disorders in insomnia was analysed.Results:Comparing primary insomnia patients with healthy controls,the functional connectivity of the VTA and NAcc was reduced in the whole brain.The brain regions with reduced functional connectivity of the VTA-l were bilater-al anterior cingulate gyrus and left orbitofrontal gyrus,the brain regions with reduced functional connectivity of the VTA-r were bi-lateral anterior cingulate gyrus,left orbitofrontal gyrus,and right precentral gyrus,and the brain regions with reduced functional connectivity of the NAcc-l were bilateral thalamus,supplementary motor area,and NAcc-r,and the brain regions with reduced functional connectivity were bilateral thalamus,supplementary motor area,and NAcc-r.The brain regions with reduced NAcc-r functional connectivity were bilateral thalamus and cerebellum.Conclusion:Sleep disorders significantly reduced the functional con-nectivity between VTA and NAcc in the reward network,suggesting that long-term sleep disorders may affect the reward process-ing ability of patients with primary insomnia and lead to emotional dysfunction in insomnia patients.关键词
功能性磁共振成像/广泛性焦虑障碍/脑功能/前扣带回/前额叶Key words
Functional magnetic resonance imaging(fMRI)/Generalised anxiety disorder/Brain function/Anterior cingu-late gyrus/Prefrontal lobe分类
医药卫生引用本文复制引用
孙曌,王小龙,靳丹阳,沈巍,冉彬艳,阚丽娜,黄禄宇,吴琼,王乙翔,康晓娜,李丹丹,王晓彤..原发性失眠患者奖赏网络关键核团在静息态fMRI功能连接的改变[J].海南医学院学报,2024,30(16):1230-1235,6.基金项目
This study was supported by National Natural Science Foundation of China Regional Science Fund Project(81861503,82260966),Hainan Provincial Natural Science Foundation Project(821RC567,823RC492),and Hainan Province Health Industry Research Project(22A200035) 国家自然科学基金地区科学基金项目(81861503,82260966) （81861503,82260966）
海南省自然科学基金项目(821RC567)(823RC492) （821RC567）
海南省卫生健康行业科研项目(22A200035) （22A200035）
