原发性失眠患者奖赏网络关键核团在静息态fMRI功能连接的改变OA北大核心CSTPCD

Objective:To observe the alterations of brain functional connectivity in the Ventral ttegmental area(VTA)and the Nucleus accumbens(NAcc)in the reward network area of primary patients using functional magnetic resonance imaging(fM-RI).Methods:Twenty-eight patients with primary insomnia were compared with 26 healthy controls,and the relationship between altered functional connectivity in the Ventral Ttegmental Area(VTA)and the Nucleus Accumbens(NAcc)and mood disorders in insomnia was analysed.Results:Comparing primary insomnia patients with healthy controls,the functional connectivity of the VTA and NAcc was reduced in the whole brain.The brain regions with reduced functional connectivity of the VTA-l were bilater-al anterior cingulate gyrus and left orbitofrontal gyrus,the brain regions with reduced functional connectivity of the VTA-r were bi-lateral anterior cingulate gyrus,left orbitofrontal gyrus,and right precentral gyrus,and the brain regions with reduced functional connectivity of the NAcc-l were bilateral thalamus,supplementary motor area,and NAcc-r,and the brain regions with reduced functional connectivity were bilateral thalamus,supplementary motor area,and NAcc-r.The brain regions with reduced NAcc-r functional connectivity were bilateral thalamus and cerebellum.Conclusion:Sleep disorders significantly reduced the functional con-nectivity between VTA and NAcc in the reward network,suggesting that long-term sleep disorders may affect the reward process-ing ability of patients with primary insomnia and lead to emotional dysfunction in insomnia patients.