海南医学院学报2024，Vol.30Issue(16)：1266-1270,5.DOI:10.13210/j.cnki.jhmu.20240423.001
基于肿瘤微环境探讨免疫检查点治疗在前列腺癌的应用及进展
Exploring the application and progress of immune checkpoint therapy in prostate cancer based on the tumor microenvironment
摘要
Abstract
Prostate cancer is one of the most common cancers in men,and the tumor microenvironment(TME)of prostate cancer patients usually features immunosuppressive properties,including impaired T-cell function,infiltration of immunosuppres-sive cells,and overexpression of immune checkpoints.Therefore,improvement in the TME is crucial for enhancing the effective-ness of immunotherapy.Therapy plans best suited to individual patients can be determined through immune monitoring,genomic analysis,and assessment of TME characteristics.However,due to significant differences between individual patients,personal-ized treatment strategies become particularly important.This review delves into the immunotherapy of prostate cancer,especially the intervention and individualized treatment strategies for TME,as well as the multilevel therapeutic combinations.It aims to pro-vide new therapeutic ideas and methods for prostate cancer patients so as to improve their survival rate and quality of life,and to provide a strong theoretical basis for the treatment of this common cancer.关键词
前列腺癌/免疫检查点治疗/肿瘤微环境Key words
Prostate cancer/Immune checkpoint therapy/Tumor microenvironment分类
医药卫生引用本文复制引用
苏超,揭育祯,王飞..基于肿瘤微环境探讨免疫检查点治疗在前列腺癌的应用及进展[J].海南医学院学报,2024,30(16):1266-1270,5.基金项目
This study was supported by Scientific Research Project Funded by Hainan Provincial Department of Science and Technology(ZDYF2021SHFZ096) 海南省科学技术厅资助的科研项目(ZDYF2021SHFZ096) （ZDYF2021SHFZ096）
