CCN家族蛋白在糖尿病肾病中的作用OA北大核心CSTPCD

Diabetes kidney disease(DKD)is a kind of kidney disease characterized by progressive renal tissue fibrosis.On the premise that diabetes is the cause of kidney damage and chronic kidney disease(CKD)caused by other reasons is excluded,type 1 and type 2 diabetes patients can be diagnosed with DKD if they have persistent albuminuria,or if the estimated glomerular filtra-tion rate has declined for more than 3 months,or if renal biopsy conforms to the pathological diagnosis of DKD.The cell communi-cation network(CCN)family of proteins is a group of intercellular matrix proteins involved in regulating important cellular patho-physiological changes such as growth,apoptosis,aging,autophagy,migration,differentiation,and inflammation.Recent studies have shown that the CCN family proteins are significantly upregulated in the DKD rat kidney model,suggesting that they play an important role in the epithelial-mesenchymal transition(EMT)of DKD renal tubular epithelial cells and the progression of renal in-terstitial fibrosis.This article reviews the role and mechanism of CCN family proteins in mediating renal injury in DKD,in order to explore potential therapeutic targets for DKD.