解放军医学杂志2024，Vol.49Issue(7)：770-775,6.DOI:10.11855/j.issn.0577-7402.0246.2024.0513
唑来膦酸治疗骨质疏松诱发急性相反应的危险因素及对治疗依从性的影响
Acute phase reaction induced by zoledronic acid in the treatment of osteoporosis:risk factors,and effects on treatment adherence
叶欣 1田欣 1邱婧文 1周波1
作者信息
- 1. 重庆医科大学附属第一医院内分泌内科,重庆 400016
- 折叠
摘要
Abstract
Objective To investigate risk factors for acute phase reaction(APR)induced by zoledronic acid(ZA)treatment in osteoporosis and its impact on treatment adherence and persistence.Methods A retrospective analysis was conducted using clinical data from 471 osteoporosis patients with a median age of 67 years,who received 5 mg ZA in the First Affiliated Hospital of Chongqing Medical University between January 2013 and January 2022.Patients were divided into two groups based on the occurrence of APR:APR group(n=79)and non-APR group(n=392).Univariate and multivariate logistic regression analyses were used to identify factors inducing APR.The treatment persistence of ZA was analyzed using Kaplan-Meier curves.In addition,treatment adherence was analyzed.Results The incidence of APR was 33.2%after the first ZA injection,and it gradually decreased with an increase in the number of infusions.The multivariate logistic regression analysis showed that the first infusion,no history of oral bisphosphonate use,and high blood phosphorus levels were independent risk factors for APR.Three-year treatment adherence and persistence in APR group were 53%and 44%,respectively,while in non-APR group,they were 52%and 42%,respectively.Kaplan-Meier analysis showed no statistically significant difference in the persistence of ZA between two groups(P＞0.05).Conclusions APR is prone to occur during ZA treatment for osteoporosis,but it does not affect the adherence and persistence of ZA treatment.First use of ZA,no history of oral bisphosphonates,and high blood phosphorus levels are independent risk factors for APR.关键词
唑来膦酸/急性相反应/骨质疏松/危险因素/依从性Key words
zoledronic acid/acute phase reaction/osteoporosis/risk factors/adherence分类
医药卫生引用本文复制引用
叶欣,田欣,邱婧文,周波..唑来膦酸治疗骨质疏松诱发急性相反应的危险因素及对治疗依从性的影响[J].解放军医学杂志,2024,49(7):770-775,6.
