解放军医学杂志2024，Vol.49Issue(7)：841-847,7.DOI:10.11855/j.issn.0577-7402.0673.2023.1010
智能响应性材料在股骨头坏死精准修复中的应用
Application of smart responsive materials in the precise repair of osteonecrosis of the femoral head
摘要
Abstract
Osteonecrosis of the femoral head(ONFH)is a common orthopedic disease,and hip preservation surgery has high clinical value in the early stages of ONFH,especially for young and middle-aged patients.However,the repair of ONFH is heterogeneous,leading to inter-individual variations in the efficacy of hip preservation.Currently,the existing tissue-engineered scaffolds in the field of hip preservation are uncontrollable after implantation,making it difficult to achieve precise repair.Smart responsive materials have good biocompatibility and self-feedback capability.By combining them with therapeutic drugs to construct stimulus-responsive drug delivery systems,new possibilities are provided for the precise repair of ONFH.This paper reviews the research progress of smart responsive materials at home and abroad.Based on the response principles of various materials and the repair characteristics of ONFH,the application prospects of various smart responsive materials such as reactive oxygen species-responsive,fluid shear stress-responsive,and light/magnetic-responsive materials are discussed and prospected in the field of precise repair for ONFH,providing new ideas for the precise treatment of ONFH.关键词
智能响应性材料/股骨头坏死/修复异质性/精准修复/应用展望Key words
smart responsive materials/femoral head osteonecrosis/heterogeneity repair/precise repair/application prospects分类
医药卫生引用本文复制引用
陈浩,席洪钟,薛鹏,何帅,谈小雪,孙光权,刘锌,江晓红,杜斌..智能响应性材料在股骨头坏死精准修复中的应用[J].解放军医学杂志,2024,49(7):841-847,7.基金项目
This work was supported by the National Natural Science Foundation of China(82074471),the Intergovernmental Cooperation Projects in the National Key Research and Development Plan of the Ministry of Science and Technology of PRC(2022YFE0196800),the Jiangsu Provincial Health and Health Commission Scientific Research Project(K2019027),and the Priority Academic Program Development of Jiangsu Higher Education Institutions(035062005001) 国家自然科学基金面上项目(82074471) （82074471）
国家重点研发计划"政府间国际科技创新合作"重点专项(2022YFE0196800) （2022YFE0196800）
江苏省卫生健康委科研项目(K2019027) （K2019027）
江苏省高校优势学科建设工程资助项目(035062005001) （035062005001）
