食品与机械2024，Vol.40Issue(7)：126-131,6.DOI:10.13652/j.spjx.1003.5788.2024.80361
高脂、高脂高果糖饮食对大鼠高尿酸血症的影响
Effect of high fat,high fat and high fructose diet on hyperuricemia in rats
摘要
Abstract
[Objective]This study aimed to investigate the effects of high fat diet and high fat and high fructose diet on uric acid level and liver and kidney function in hyperuricemia(HUA)rats.[Methods]24 rats were randomly divided into control group,model group,high-fat diet group and high-fat and high-fructose diet group.All rats were fed with the corresponding diets,except the control group,500 mg/kg potassium oxazinate and 100 mg/kg adenine per day.After 6 weeks,serum biochemical indexes such as uric acid and creatinine were determined,and pathological examination of kidney and liver was performed.[Results]The uric acid content of control group,model group,high-fat diet group and high-fat high-fructose diet group were 118.10,319.05,325.71,456.10 μmol/L,respectively.The levels of uric acid and creatinine in the high-fat diet group were not significantly different from those in the model group,but the kidney injury and liver fat accumulation were more serious.The uric acid in the high-fat and high-fructose group was significantly higher than that in the model group,and the degree of kidney injury and liver fat accumulation was more serious than that in the model group.[Conclusion]High-fat diet cannot further increase the uric acid content of HUA rats,but can aggravate the liver and kidney damage of HUA rats.High-fat and high-fructose diet will further increase the uric acid content of HUA rats,and aggravate kidney injury and liver fat accumulation.Hyperuricemia group should pay attention to control the intake of dietary fat and fructose.关键词
高尿酸血症/腺嘌呤/高脂饮食/高脂高果糖饮食Key words
hyperuricemia/adenine/high-fat diet/high fat and high fructose diet引用本文复制引用
车荧娟,陈妍,陈婷婷,罗舜菁,刘成梅..高脂、高脂高果糖饮食对大鼠高尿酸血症的影响[J].食品与机械,2024,40(7):126-131,6.基金项目
江西省"双千计划"科技创新高端人才项目-自然科学类(编号:jxsq2023201042) （编号:jxsq2023201042）
江西省重点研发计划(编号:20232BBF60023) （编号:20232BBF60023）
江西省中央引导地方科技发展资金项目(编号:20221ZDD02001) （编号:20221ZDD02001）
全国重点实验室项目(编号:20232BCD44005) （编号:20232BCD44005）
