影响H9N2亚型禽流感病毒生物学特性的关键氨基酸位点分析OA
Analysis on the Key Amino Acid Sites Affecting the Biological Properties of H9N2 Subtype Avian Influenza Virus
H9N2 亚型禽流感病毒是在我国家禽中流行最为广泛的亚型,严重影响养禽业健康发展,具有感染哺乳动物的能力.可感染人类的H5N1、H7N9、H10N8 和H3N8 等新型流感病毒中多次发现H9N2 亚型禽流感病毒的内部基因,而这些感染人类的新型流感病毒对公共卫生安全造成了巨大威胁.文章围绕H9N2 亚型禽流感病毒,总结了影响该亚型病毒致病性、受体结合、复制能力以及在家禽或哺乳动物中与传播有关的关键功能氨基酸位点突变的研究进展,以期进一步解析H9N2 亚型禽流感病毒及其内部基因在新型流感病毒产生过程中的机制和作用.
For various subtypes of avian influenza virus(AIV),H9N2 subtype is the most prevalent one in poultry in China to the most extensive degree,which seriously affects healthy development of poultry industry,and may infect mammals.Internal genes of H9N2 subtype AIV have been found in novel influenza viruses such as H5N1,H7N9,H10N8 and H3N8 that may infect human beings,posing a great threat to public health security.Here,research progress of mutations at key functional amino acid sites affecting viral pathogenicity,receptor binding,replication capacity and transmission in poultry or mammals was summarized based on H9N2 subtype virus,with a view to interpreting the mechanisms and roles of H9N2 subtype virus and its internal genes in the generation of novel influenza viruses.
周婉婷;彭程;蒋文明;宋厚辉;刘朔;刘华雷
浙江农林大学动物科技学院·动物医学院,浙江杭州 311300中国动物卫生与流行病学中心,农业农村部动物生物安全风险预警及防控重点实验室(南方),青岛市动物生物安全重点实验室,山东青岛 266032
畜牧业
禽流感病毒H9N2氨基酸位点生物学特性突变
AIVH9N2amino acid sitebiological propertymutation
《中国动物检疫》 2024 (008)
20-27 / 8
国家重点研发计划项目(2022YFF0802400)
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