中国感染控制杂志2024，Vol.23Issue(8)：963-974,12.DOI:10.12138/j.issn.1671-9638.20245426
湖南省细菌耐药监测网2012-2021年胆汁分离细菌耐药性监测报告
Antimicrobial resistance of bacteria isolated from bile:surveillance report from Hunan Province Antimicrobial Resistance Surveillance System,2012-2021
李晨 1郑铭 2付陈超 2任南 3黄勋 3吴安华 3陈丽华 4李艳明 5刘君 6宁兴旺 7石国民 8邬靖敏 9杨怀德 10袁红霞11
作者信息
- 1. 浏阳市中医医院检验科,湖南浏阳 410300
- 2. 中南大学湘雅医院医院感染控制中心,湖南长沙 410008||湖南省细菌耐药监测网办公室,湖南长沙 410008
- 3. 中南大学湘雅医院医院感染控制中心,湖南长沙 410008||湖南省细菌耐药监测网办公室,湖南长沙 410008||湖南省医院感染管理质量控制中心,湖南长沙 410008||国家老年疾病临床医学研究中心(湘雅医院),湖南长沙 410008
- 4. 中南大学湘雅三医院检验科,湖南长沙 410013
- 5. 中南大学湘雅医院检验科,湖南长沙 410008
- 6. 湘潭市中心医院检验科,湖南湘潭 411100
- 7. 湖南中医药大学第一附属医院医学检验与病理中心,湖南长沙 410011
- 8. 长沙市中心医院检验科,湖南长沙 410004
- 9. 长沙市第一医院检验科,湖南长沙 410005
- 10. 张家界市人民医院检验科,湖南张家界 427000
- 11. 郴州市第一人民医院检验医学中心,湖南郴州 423000
- 折叠
摘要
Abstract
Objective To analyze the distribution and changing trend of antimicrobial resistance of bacteria isolated from bile from Hunan Province Antimicrobial Resistance Surveillance System.Methods Data of pathogens isolated from bile from Hunan Province Antimicrobial Resistance Surveillance System from 2012 to 2021 were collected.The constituent of bacteria and antimicrobial susceptibility testing results were analyzed by WHONET 5.6 software.Changes in antimicrobial resistance was analyze by trend chi-square test.Results The major pathogenic bacteria isolated from bile were Gram-negative bacteria,accounting for 70.84％.The top three isolated Gram-negative pathogens were Escherichia coli(30.14％),Klebsiella pneumoniae(12.15％),and Pseudomonas aeruginosa(5.18％),and the top two Gram-positive bacteria were Enterococcus faecium(10.34％)and Enterococcus faecalis(9.52％).The resistance rates of Klebsiella pneumoniae and Escherichia coli to imipenem were highest in 2012-2013,being 15.7％and 14.9％,respectively,presenting an downward trend(P＜0.05);resistance rates to piperacillin/tazobactam and cefoperazone/sulbactam were＜24％,presenting an upward trend year by year(P＜0.05);the sus-ceptibility rate to amikacin was＞94％,to levofloxacin and ciprofloxacin was 15.5％-65.2％.The highest resis-tance rate of Pseudomonas aeruginosa to imipenem(32.0％)was higher than that of meropenem(22.9％),resis-tance rates to piperacillin/tazobactam and cefoperazone/sulbactam were＜19％.The highest resistance rates of Acinetobacter baumannii to imipenem and meropenem were 59.4％and 62.6％,respectively,resistance rate to cefo-perazone/sulbactam was＜48％,presenting an upward trend(P＜0.05);the highest resistance rate to ciprofloxa-cin(60.8％)was higher than levofloxacin(48.7％);resistance rate to tigecycline was＜8％.The resistance rates of Enterococcus faecium to penicillin and ampicillin were both higher than those of Enterococcus faecalis,presenting an upward trend(P＜0.05).Resistance rate of Enterococcus faecium to vancomycin was lower than that of Entero-coccus faecalis.The resistance rates of Enterococcus faecium to vancomycin and linezolid were 0.5％-4.5％and 0.5％-3.4％,respectively;resistance rates of Enterococcus faecalis to vancomycin and linezolid were 0.2％-1.7％and 0.5％-3.5％,respectively(both P＜0.05),all presenting a downward trend(all P＜0.05).Conclusion Pathogenic bacteria isolated from bile are mainly related to the intestinal flora.The resistance rates of Enterococcus faecalis and Enterococcus faecium to vancomycin and linezolid as well as resistance rate of Enterobacterales to car-bapenem antibiotics all present a downward trend.关键词
胆汁/胆道感染/病原菌/耐药性/湖南省细菌耐药监测网Key words
bile/biliary tract infection/pathogen/antimicrobial resistance/Hunan Province Antimicrobial Re-sistance Surveillance System分类
医药卫生引用本文复制引用
李晨,郑铭,付陈超,任南,黄勋,吴安华,陈丽华,李艳明,刘君,宁兴旺,石国民,邬靖敏,杨怀德,袁红霞..湖南省细菌耐药监测网2012-2021年胆汁分离细菌耐药性监测报告[J].中国感染控制杂志,2024,23(8):963-974,12.
