肿瘤防治研究2024，Vol.51Issue(8)：617-624,8.DOI:10.3971/j.issn.1000-8578.2024.24.0335
甲状腺未分化癌的靶向治疗进展
Progress of Targeted Therapy for Anaplastic Thyroid Cancer
摘要
Abstract
Anaplastic thyroid cancer,an extremely rare malignant tumor of the thyroid gland,is a major cause of mortality in thyroid cancer because of its aggressiveness and poor prognosis.Anaplastic thyroid cancer is typically challenging to treat surgically,and the efficacy of traditional radiotherapy and chemotherapy remains unclear.Meanwhile,the emergence of targeted therapy has radically transformed the traditional mode of tumor treatment.Anti-tumor effects can be achieved by specifically targeting tumor-associated molecules and signaling pathways.Compared with conventional chemotherapy,targeted therapy is able to more precisely target tumor cells while minimizing damage to normal cells.With the advancement of clinical trials on targeted therapy,the use of targeted drugs has been observed to significantly improve overall survival of patients with anaplastic thyroid cancer.Targeted therapy and tumor-related signaling pathways have emerged as research hotspots in the treatment of anaplastic thyroid cancer.This article offers an overview of the progress of targeted therapy for anaplastic thyroid cancer,incorporating current research on targeted drugs in the treatment of this condition.关键词
甲状腺未分化癌/靶向治疗/信号通路/基因突变Key words
Anaplastic thyroid cancer/Targeted therapy/Signaling pathway/Genetic mutation分类
医药卫生引用本文复制引用
殷德涛,刘维豪..甲状腺未分化癌的靶向治疗进展[J].肿瘤防治研究,2024,51(8):617-624,8.基金项目
Henan Provincial Natural Science Foundation General Project(No.222300420568) （No.222300420568）
The Major Plan Project for Medical Science and Technology Research in Henan Province(No.SBGJ202101014) （No.SBGJ202101014）
The Henan Province Major Special Project for Traditional Chinese Medicine Research(No.20-21ZYZD14) （No.20-21ZYZD14）
The Henan Province Youth Medical Technology Innovation Leading Talent Project(No.YXKC2020015)河南省自然科学基金面上项目(222300420568) （No.YXKC2020015）
河南省医学科技攻关重大计划项目(SBGJ202101014) （SBGJ202101014）
河南省中医药研究河南省中青年医学重大专项(20-21ZYZD14) （20-21ZYZD14）
河南省中青年医学科技创新领军人才项目(YXKC2020015) （YXKC2020015）
