磁共振弹性成像在宫颈癌诊断中的初步应用研究OA北大核心CSTPCD

Objective:To explore the clinical value of magnetic resonance elastography (MRE) in cervical cancer. Materials and Methods:In this prospective study,a total of 39 patients diagnosed with cervical cancer (cervical cancer group) were prospectively recruited,along with 39 healthy female volunteers (control group) matched for age and body mass index (BMI). The participants underwent routine cervical MRI and MRE examinations with a frequency of 60 Hz. The stiffness values of the cervix were measured in both groups,along with the volume and depth of infiltration of tumors in the cervical cancer group,were measured. Tumor staging was collected for patients in the cervical cancer group. A paired sample t-test was used to compare the elasticity values between the cervical cancer group and the healthy control group. Spearman's rank correlation coefficient and receiver operating characteristic (ROC) curve analysis were conducted to assess the correlation between stiffness values,tumor volume,infiltration depth,and cervical cancer staging,as well as the diagnostic efficiency of staging cervical cancer. Results:The average stiffness value of the cervical cancer group[(5.76±0.99)]kPa was significantly higher than the healthy control group[(2.94±0.25) kPa;P<0.001]. Stiffness values,tumor volume,and infiltration depth showed statistically significant differences between early (≤ⅡA stage) and advanced stage (≥ⅡB stage) cervical cancer and were positively correlated with cervical cancer staging (r=0.439,0.384,0.322;P<0.05). The diagnostic efficacy of stiffness values was superior to tumor volume and infiltration depth,with the area under the curve (AUC) of ROC for stiffness values (0.754)>tumor volume (0.722)>infiltration depth (0.687). Conclusions:MRE technology can serve as a non-invasive adjunct diagnostic tool for the diagnosis and staging of cervical cancer,holding potential clinical application prospects in the research and formulation of treatment strategies for cervical cancer.