表没食子儿茶素没食子酸酯预防并改善非酒精性脂肪性肝病的作用机制及研究进展OA北大核心CSTPCD

The incidence of nonalcoholic fatty liver disease (NAFLD) is increasing year by year and there is no specific drug available. The active ingredient of green tea,epigallocatechin gallate (EGCG),has been widely proven to have a favorable ameliorative effect on NAFLD in the low dose range. Some of the mechanisms by which EGCG delays the development of NAFLD through anti-oxidative stress,anti-inflammation,inhibition of iron death,reduction of lipogenesis,up-regulation of autophagy,modulation of intestinal flora,and reduction of bile acid metabolism were summarized in this paper,so as to provide insights for in-depth research on improving NAFLD.