食品工业科技2024，Vol.45Issue(17)：406-415,10.DOI:10.13386/j.issn1002-0306.2023090169
基于肠-脑轴探讨植物多糖干预肠道菌群抗抑郁的研究进展
Exploring the Antidepressant Effects of Plant Polysaccharides on Gut Microbiota Based on the Gut-Brain Axis
摘要
Abstract
Depression is a severe emotional disorder characterized by persistent and prominent clinical symptoms,such as sadness and a loss of interest or pleasure.The pathogenesis of depression is intricate,and in recent years,investigations into the gut-brain axis theory have offered viable endogenous mechanisms for further exploration of depression.This theory is supported by evidence of disrupted gut microbiota,elevated inflammation markers,and deviant neurotransmitter levels in individuals with depression.Plant polysaccharides exhibit various biological activities and have been shown to modulate different metabolic pathways within the gut microbiota,thus impacting depression through the gut-brain axis.Nevertheless,a comprehensive summary of their mechanisms of action is currently lacking.Therefore,this study explores the potential antidepressant effects of plant polysaccharides by examining their regulation of short-chain fatty acids,lipopolysaccharides,and tryptophan metabolism within the gut microbiota and the gut-brain axis.Through a comprehensive analysis of recent literature,this article reviews the intricate relationships between various plant polysaccharides and their mechanisms in alleviating depression.It provides a theoretical basis for understanding how plant polysaccharides act as antidepressants and for developing resources for antidepressant polysaccharides.关键词
多糖/肠-脑轴/肠道菌群/抑郁症/短链脂肪酸Key words
polysaccharide/gut-brain axis/gut microbiota/depression/short chain fatty acids分类
轻工纺织引用本文复制引用
蒋玉珍,刘俊熙,杨扬,钟膳蔚,黄安晴,陈晓程,杜冰,黎攀..基于肠-脑轴探讨植物多糖干预肠道菌群抗抑郁的研究进展[J].食品工业科技,2024,45(17):406-415,10.基金项目
国家自然科学基金青年基金(32202058) （32202058）
广西药用资源保护与遗传改良重点实验室资助课题(KL2023KF03). （KL2023KF03）
