食品科学2024，Vol.45Issue(17)：80-87,8.DOI:10.7506/spkx1002-6630-20231206-043
鸡蛋过敏人群肠道菌群特征及其与血清细胞因子的相关性
Characteristics of Intestinal Flora in Egg-Allergic Population and Their Correlation with Serum Cytokines
摘要
Abstract
Objective:The present study intended to analyze the characteristics of intestinal floral composition and the relationship with serum cytokines in individuals with egg allergy.Methods:A total of 20 subjects were recruited in this study.The abundance and composition of intestinal flora were determined by 16S rRNA gene sequencing,and the serum levels of food allergy-related cytokines such as interleukin-4(IL-4)and IL-5 were measured by enzyme immunoassay.The differences in the structure of intestinal flora and the levels of cytokines were compared between the egg allergy and control groups and the correlation between them was analyzed.Results:The serum levels of IL-4 and IL-5 were significantly higher in the egg allergy group compared with the control group(P＜0.05).16S rRNA gene sequencing showed that Betaproteobacteriales,Burkholderiaceae and Eubacterium_hallii_group were significantly enriched in the allergy group(P＜0.05).Spearman's correlation analysis revealed a negative correlation between the abundance of Weissella cibaria and Escherichia and the serum levels of IL-4 and IL-13.However,the abundance of Burkholderiaceae and uncultured_Parasutterella abundance was positively correlated with transforming growth factor betal(TGF-βi)and IL-13.Conclusion:This study provides a scientific basis for determining the specific intestinal flora of egg-allergic individuals and for exploring the implication of intestinal flora in preventing or treating egg allergy.关键词
鸡蛋过敏/肠道菌群/细胞因子/相关性Key words
egg allergy/intestinal flora/cytokines/correlation分类
临床医学引用本文复制引用
赵童,杨善平,陈玲玲,赵莲英,刘冬青,麻微微,周催..鸡蛋过敏人群肠道菌群特征及其与血清细胞因子的相关性[J].食品科学,2024,45(17):80-87,8.基金项目
国家自然科学基金面上项目(82273633) （82273633）
