金黄色葡萄球菌B型肠毒素热变性过程:源于圆二色光谱及分子动力学模拟的启示OA北大核心CSTPCD
Temperature-Induced Unfolding Pathway of Staphylococcal Enterotoxin B:Insights from Circular Dichroism and Molecular Dynamics Simulation
本实验在298～371 K和298～500 K温度范围内,分别利用圆二色(circular dichroism,CD)光谱和分子动力学(molecular dynamics,MD)模拟研究加热过程中金黄色葡萄球菌B型肠毒素(staphylococcal enterotoxin B,SEB)的热变性过程,探索实验与模拟之间的关系.对SEB二级结构研究发现,在室温条件下,CD谱图与MD模拟结果高度一致;在加热条件下,CD谱图拟合出的螺旋、折叠和无规卷…查看全部>>
In this study,circular dichroism(CD)and molecular dynamics(MD)simulation were used to investigate the thermal unfolding pathway of staphylococcal enterotoxin B(SEB)at temperatures of 298-371 and 298-500 K,and the relationship between the experimental and simulation results were explored.Our computational findings on the secondary structure of SEB showed that at room temperature,the CD spectroscopic results were highly consistent with the MD results.Moreover,…查看全部>>
刘骥;张诗雨;曾瑜;邓依
西南民族大学青藏高原研究院,四川 成都 610041西南民族大学食品科学与技术学院,四川 成都 610041西南民族大学食品科学与技术学院,四川 成都 610041五粮液股份有限公司,四川 宜宾 644000
轻工业
金黄色葡萄球菌B型肠毒素圆二色光谱分子动力学模拟热变性解折叠
staphylococcal enterotoxin Bcircular dichroismmolecular dynamics simulationstemperature-induced unfolding
《食品科学》 2024 (18)
55-76,22
西南民族大学中央高校基本科研业务费专项资金项目(2023NZYQN99)
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