近红外Ⅱ区有机荧光探针的构筑与生物成像研究进展OA
Design of Near-Infrared Ⅱ Organic Fluorescence Probes and Their Progress in Bioimaging
荧光成像技术凭借灵敏度高、特异性强和可实时成像等优点,被广泛应用于生物医学和疾病诊断等领域.近红外Ⅱ区(NIR-Ⅱ,1000～1700 nm)荧光成像技术,能够有效弥补可见光(390～780 nm)荧光成像过程中组织穿透性差、生物样品光吸收和自发荧光干扰、信噪比低等不足,提高荧光成像的灵敏度、分辨率和组织穿透度,极大推动了生物医学成像发展.目前,涌现出较多荧光成像技术,其中有机荧光探针凭借其生物兼容性好、毒性较低和廉价易得等突出优势受到越来越多关注.通过系统性概括近年来NIR-Ⅱ有机小分子荧光探针的研究进展,按识别对象和生物成像用途分类介绍其设计原理及生物应用,并对该类探针在疾病诊断和手术荧光示踪方面进行了探讨,为NIR-Ⅱ有机小分子荧光探针的未来发展奠定基础.
Fluorescence imaging technology is widely used in the fields of biomedicine and disease diagnosis due to its advantages of high sensi-tivity,strong specificity and real-time imaging.Near-infrared Ⅱ region(NIR-Ⅱ,1000-1700 nm)fluorescence imaging technology can ef-fectively overcome the poor tissue penetration,light absorption and autofluorescence interference of biological samples,and low signal-to-noise ratio in the process of visible light(390-780 nm)fluorescence imaging and improve fluorescence imaging sensitivity,resolution and tis-sue penetration of fluorescence imaging.In recent years,organic fluorescent probes have received more and more attention due to their unique advantages such as good biocompatibility,low toxicity and low cost.We systematically introduce the research progress of organic fluorescent probes in the near-infrared Ⅱ region in recent years according to the classification of identification objects and biological imaging applications.Moreover,we also discuss their application in disease diagnosis and fluorescent tracking,laying the foundation for the development of organic fluorescent probes in the near-infrared Ⅱ region.
王敏娟;王兴凤;包永芬;单士刚;欧莹宝;魏明杰
湖北科技学院 药学院,湖北 咸宁 437100湖北科技学院 基础医学院,湖北 咸宁 437100湖北科技学院 公共卫生与健康学院,湖北 咸宁 437100
化学
近红外Ⅱ区有机小分子探针荧光探针生物成像
Near Infrared Ⅱ RegionOrganic Small Molecule ProbesFluorescent ProbeBioimaging
《云南化工》 2024 (008)
6-14 / 9
湖北省自然科学基金资助项目(No.2022CFB781);湖北科技学院博士启动资助项目(No.170562).
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