免疫类器官在肿瘤免疫研究中的应用与挑战OA北大核心CSTPCD

Immunotherapy has emerged as a groundbreaking approach that has revolutionized tumor treatment and revitalized research in tumor immunology.At the forefront of this innovation is immune-organoid,which has become an indispensable tool in tumor immunology research.These models excel in reconstructing the tumor immune microenvironment,faithfully mimicking the response mechanisms and interactions of immune cells.Consequently,they have garnered widespread adoption in tumor immunology research.The innovative immune-organoid models encompass two primary categories:those derived from immune organs and those involving co-cultures of tumor organoids with immune cells.These models offer a versatile platform with applications spanning diverse domains,including the elucidation of tumorigenesis mechanisms,drug screening processes,the acceleration of cancer vaccine development,and the guidance of personalized therapeutic strategies.In this review,we provide a comprehensive summary of the current culture methods and status of immune-organoid.We also explore the wide application of immune-organoid in tumor immunology,while addressing the challenges they face and offering insights into future directions for this promising technology.