中国肿瘤生物治疗杂志2024，Vol.31Issue(8)：743-751,9.DOI:10.3872/j.issn.1007-385x.2024.08.001
免疫类器官在肿瘤免疫研究中的应用与挑战
Application and challenge of immune-organoid in immuno-oncology
摘要
Abstract
Immunotherapy has emerged as a groundbreaking approach that has revolutionized tumor treatment and revitalized research in tumor immunology.At the forefront of this innovation is immune-organoid,which has become an indispensable tool in tumor immunology research.These models excel in reconstructing the tumor immune microenvironment,faithfully mimicking the response mechanisms and interactions of immune cells.Consequently,they have garnered widespread adoption in tumor immunology research.The innovative immune-organoid models encompass two primary categories:those derived from immune organs and those involving co-cultures of tumor organoids with immune cells.These models offer a versatile platform with applications spanning diverse domains,including the elucidation of tumorigenesis mechanisms,drug screening processes,the acceleration of cancer vaccine development,and the guidance of personalized therapeutic strategies.In this review,we provide a comprehensive summary of the current culture methods and status of immune-organoid.We also explore the wide application of immune-organoid in tumor immunology,while addressing the challenges they face and offering insights into future directions for this promising technology.关键词
免疫类器官/肿瘤免疫/免疫疗法/肿瘤微环境Key words
immune-organoid/immuno-oncology/immunotherapy/tumour microenvironment(TME)分类
医药卫生引用本文复制引用
王雪婷,高春记,张斌..免疫类器官在肿瘤免疫研究中的应用与挑战[J].中国肿瘤生物治疗杂志,2024,31(8):743-751,9.基金项目
军队生物安全项目(No.23SWAQ17) （No.23SWAQ17）
