中国合理用药探索2024，Vol.21Issue(8)：33-47,15.DOI:10.3969/j.issn.2096-3327.2024.08.002
上呼吸道益生菌Biohalo23用于呼吸道感染及中耳炎的专家共识——现有循证科学依据及未来研究建议
Expert Consensus on the Use of Upper Respiratory Tract Probiotic Biohalo23 in Respiratory Tract Infection and Otitis Media:Available Evidence-Based Scientific Evidence and Recommendations for Future Research
王强 1孙凯 2沈关心 3张亚同 4成晓玲 5郭智 6刘洋 7夏立红 8刘志刚 9郑俊青 9张子和10
作者信息
- 1. 武汉科技大学医学院,武汉 430065
- 2. 山东第一医科大学第一附属医院,济南 250014
- 3. 华中科技大学同济医学院,武汉 430030
- 4. 北京医院,北京 100730
- 5. 首都医科大学附属北京儿童医院,北京 100045
- 6. 华中科技大学协和深圳医院,深圳 518052
- 7. 武汉亚心总医院,武汉 430056
- 8. 山东中医药大学附属医院,济南 250014
- 9. 济南市妇幼保健院,济南 250001
- 10. 山东省妇幼保健院,济南 250000
- 折叠
摘要
Abstract
The respiratory tract microbiota determines whether the host has predisposition for respiratory tract infection,and builds up the first line of defence against infection together with the host immune system.The characterization of respiratory flora are closely related to early-life asymptomatic viral exposure,early-life respiratory infection,allergic constitution,and antibiotic exposure during pregnancy or early life,constituting important factors underlying future recurrent respiratory infection or allergic constitution.In recent years,many attempts through studies have been tried to explore the effects of human microbiome-based interventions on the regulation of host immunity and the prevention of respiratory tract infections.However,the heterogeneous and inconsistent reproducibility between studies resulted in inconsistent opinions among physicians in terms of the recommendation of probiotics to patients.As an evidence-based research method recommended by academia in recent years,probiotic finished product research is an effective method to promote the benign development of probiotics industry.The research results are more consistent with the administration outcomes in a real-world setting and hence conducive to experts'clinical use and also serving as reference for consumer when making choice.On the ground of applying upper respiratory tract probiotic Biohalo23 in clinical practice in China and Europe and relevant positive feedback from patients,the expert panel supposes that the upper respiratory tract probiotic Biohalo23,with evidence-based scientific evidence and consistent and positive clinical research results across multiple studies,can be considered as a"tool"for physicians to recommend to patients in need on the basis of standard drug therapy to improve quality of life associated with respiratory tract infection and reduce the burden of predisposition for respiratory tract infection,and the panel also encourages physicians to devote attention to new research areas of the development and medical application of the respiratory microbiota,and believes that respiratory microbiota-based intervention is of great potential for better disease management.关键词
上呼吸道益生菌Biohalo23/呼吸道感染/中耳炎/专家共识/循证科学依据Key words
upper respiratory tract probiotic Biohalo23/respiratory tract infection/otitis media/expert consensus/evidence-based scientific evidence分类
医药卫生引用本文复制引用
王强,孙凯,沈关心,张亚同,成晓玲,郭智,刘洋,夏立红,刘志刚,郑俊青,张子和..上呼吸道益生菌Biohalo23用于呼吸道感染及中耳炎的专家共识——现有循证科学依据及未来研究建议[J].中国合理用药探索,2024,21(8):33-47,15.
