上呼吸道益生菌Biohalo23用于呼吸道感染及中耳炎的专家共识——现有循证科学依据及未来研究建议OA

The respiratory tract microbiota determines whether the host has predisposition for respiratory tract infection,and builds up the first line of defence against infection together with the host immune system.The characterization of respiratory flora are closely related to early-life asymptomatic viral exposure,early-life respiratory infection,allergic constitution,and antibiotic exposure during pregnancy or early life,constituting important factors underlying future recurrent respiratory infection or allergic constitution.In recent years,many attempts through studies have been tried to explore the effects of human microbiome-based interventions on the regulation of host immunity and the prevention of respiratory tract infections.However,the heterogeneous and inconsistent reproducibility between studies resulted in inconsistent opinions among physicians in terms of the recommendation of probiotics to patients.As an evidence-based research method recommended by academia in recent years,probiotic finished product research is an effective method to promote the benign development of probiotics industry.The research results are more consistent with the administration outcomes in a real-world setting and hence conducive to experts'clinical use and also serving as reference for consumer when making choice.On the ground of applying upper respiratory tract probiotic Biohalo23 in clinical practice in China and Europe and relevant positive feedback from patients,the expert panel supposes that the upper respiratory tract probiotic Biohalo23,with evidence-based scientific evidence and consistent and positive clinical research results across multiple studies,can be considered as a"tool"for physicians to recommend to patients in need on the basis of standard drug therapy to improve quality of life associated with respiratory tract infection and reduce the burden of predisposition for respiratory tract infection,and the panel also encourages physicians to devote attention to new research areas of the development and medical application of the respiratory microbiota,and believes that respiratory microbiota-based intervention is of great potential for better disease management.