中国中医药信息杂志2024，Vol.31Issue(9)：179-184,6.DOI:10.19879/j.cnki.1005-5304.202309504
中药基于缺氧微环境调控糖代谢重编程干预胃癌前病变研究进展
Research Progress in Chinese Materia Medica Regulation of Glucose Metabolism Reprogramming Intervention in Gastric Precancerous Lesions Based on Hypoxia Microenvironment
摘要
Abstract
Precancerous lesions of gastric cancer is a key stage in the development of gastric cancer.The reprogramming of glucose metabolism is a prominent feature of precancerous lesions of gastric cancer.Hypoxic microenvironment and hypoxia-inducible factors are important factors influencing the occurrence of glucose metabolic reprogramming.This article summarized the relationship between hypoxic microenvironment and the reprogramming of glucose metabolism in precancerous lesions of gastric cancer,and concluded the relevant research on TCM compounds and effective components to improve hypoxic microenvironment and further regulate glycolysis for the treatment of this disease.It was concluded that the mechanism may be the inhibition of angiogenesis,regulation of signaling pathways and key proteins of glycolysis,expression of multiple enzymes,reduction of lactate secretion,inhibition of cell malignant proliferation and invasion.It explored the mechanism of Chinese materia medica in improving hypoxic microenvironment and regulating glycolysis,so as to provide reference for the prevention and treatment of precancerous lesions of gastric cancer.关键词
胃癌前病变/缺氧微环境/糖代谢重编程/糖酵解/中药Key words
precancerous lesions of gastric cancer/hypoxic microenvironment/glucose metabolism reprogramming/glycolysis/Chinese materia medica分类
中医学引用本文复制引用
王晓龙,宋瑞平,豆鹏程,封壮壮,孙小伟,雷东旭,杨静,南青山,舒劲..中药基于缺氧微环境调控糖代谢重编程干预胃癌前病变研究进展[J].中国中医药信息杂志,2024,31(9):179-184,6.基金项目
国家自然科学基金(82060860) （82060860）
甘肃省自然科学基金(21JR7RA588) （21JR7RA588）
