儿童难治性脓毒性休克的挽救性策略OA北大核心CSTPCD

Refractory septic shock(RSS)is the most common cause of early death in children with septic shock.The mortality of RSS remains high.How to successfully diagnose and treat RSS has become the focus and difficulty of pediatric intensive care unit(PICU),and it is also an important means to reduce the mortality of SS.RSS often presents with refractory shock and persistent hyperlactacemia.Catecholamines are the first-line drugs to improve hypotension and hypoperfusion.However,with the increase of drug dosage,related complications also increase significantly,and new strategies need to be further sought.At present,there is no clear and unified saving strategy for children's RSS.The article review the updating of RSS guidelines,suggestions on hemodynamic evaluation methods,progress of therapeutic drugs and treatment methods,aiming to provide help for clinical optimization of RSS treatment.