食品科学2024，Vol.45Issue(19)：65-76,12.DOI:10.7506/spkx1002-6630-20240312-077
嗜黏蛋白阿克曼氏菌ONE对高胆固醇血症小鼠的改善效果
Alleviating Effect of Akkermansia muciniphila ONE on Hypercholesterolemia in Mice
摘要
Abstract
The purpose of this study was to investigate the alleviating effect of Akkermansia muciniphila ONE(AKK ONE)on high-cholesterol diet-induced hypercholesterolemia in mice.Four-week gavage of AKK ONE was found to improve blood lipid levels in hypercholesterolemic mice.Specifically,it significantly reduced the contents of total cholesterol(TC)and low-density lipoprotein cholesterol(LDL-C)in serum and liver,increased the content of high-density lipoprotein cholesterol(HDL-C),alleviated liver damage,reduced the levels of serum alanine aminotransferase(ALT),aspartate aminotransferase(AST)and total bile acid(TBA),and improved fasting blood glucose levels and glucose tolerance.Further analysis of intestinal flora and metabolites showed that AKK ONE significantly increased the abundance of Faecalibaculum,Oscillospira,Bacteroides and Akkermansia in the intestine of mice,increased the contents of short-chain fatty acids(SCFAs)including acetic acid,isobutyric acid and valeric acid,and regulated the composition of intestinal bile acids(BAs)especially secondary BAs.In summary,AKK ONE improved high cholesterol diet-induced hypercholesterolemia by regulating the abundance of intestinal flora,especially increasing the abundance of SCFAs-producing bacteria,thereby increasing the contents of fecal SCFAs and enhancing the transformation of cholesterol into BAs.This study provides a new insight into the relationship between next-generation probiotics and intestinal flora and metabolites,which will serve as the basis for the potential application of AKK ONE in alleviating hypercholesterolemia.关键词
嗜黏蛋白阿克曼氏菌ONE/高胆固醇血症/肠道菌群/短链脂肪酸/胆汁酸Key words
Akkermansia muciniphila ONE/hypercholesterolemia/intestinal flora/short-chain fatty acid/bile acid分类
轻工业引用本文复制引用
李月,张红岩,马新,郁雪平,任大勇..嗜黏蛋白阿克曼氏菌ONE对高胆固醇血症小鼠的改善效果[J].食品科学,2024,45(19):65-76,12.基金项目
吉林省科技厅中青年科技创新创业卓越人才(团队)项目(20220508106RC) （团队）
