食品科学2024，Vol.45Issue(19)：317-331,15.DOI:10.7506/spkx1002-6630-20240218-084
高分辨质谱非靶向筛查分析方法在食品化学危害物监测中的研究进展
Research Progress on Non-targeted Screening Methods with High Resolution Mass Spectrometry for Food Chemical Hazards Monitoring
摘要
Abstract
Monitoring of food chemical hazards(FCHs)is crucial to ensure food quality and safety.Non-targeted screening(NTS)is an effective technique to identify a wide range of potential and unknown FCHs using high performance liquid chromatography/high performance gel chromatography-high resolution mass spectrometry(HPLC/HPGC-HRMS)platforms with strong separation capability,high mass resolution and high mass accuracy.However,the development and application of NTS methods are still challenging due to the wide variety of FCHs,the large amount of acquired data,and the cumbersome analysis process.Selecting an appropriate data acquisition mode and an effective non-targeted data analysis strategy are essential to successfully identify potential and unknown FCHs.This paper reviews the data acquisition modes,analysis processes and strategies involved in NTS and the application of NTS for FCHs screening in the past five years,in order to promote the development of NTS methods for FCHs and to provide support for the early warning of risk factors in foods and food safety monitoring.关键词
食品化学危害物/高分辨质谱/非靶向筛查/数据采集模式/分析策略/食品质量与安全Key words
food chemical hazards/high resolution mass spectrometry/non-targeted screening/data acquisition mode/analysis strategy/food quality and safety分类
轻工纺织引用本文复制引用
石培育,陈燕秋,陈世奇,戴琴,吴文林,宋娟,蒋锡兰,肖全伟,李绍波,姚静,吴恋,刘川,林浩..高分辨质谱非靶向筛查分析方法在食品化学危害物监测中的研究进展[J].食品科学,2024,45(19):317-331,15.基金项目
"十四五"国家重点研发计划重点专项(2022YFF0710405) （2022YFF0710405）
国家市场监督管理总局重点实验室(调味品监管技术)开放课题(KLCST-2022-03) （调味品监管技术）
四川省科技计划重点研发项目(2024YFFK0428) （2024YFFK0428）
2023年和2024年成都市食品安全风险研究项目(2023spfx01 （）
2024spfx01) （）
