中国食品添加剂2024，Vol.35Issue(10)：108-117,10.DOI:10.19804/j.issn1006-2513.2024.10.013
薰衣草精油的精制分离与抗炎活性研究
Refinement and seperation of lavender essential oil and its anti-inflammatory activity
摘要
Abstract
To investigate the effects of exposure time and composition on the activity of lavender essential oil(LEO),the chemical compositions of LEO and its purified light and heavy fractions(LLEO and HLEO)after refinement and separation were detected by gas chromatography-mass spectrometry(GC-MS).LPS-induced RAW264.7 cells inflammation model was used to investigate the relationship between the anti-inflammatory activity and exposure time of LEO and the difference of anti-inflammatory activity between light and heavy fractions.The results showed that linalyl acetate,linalool and lavender acetate were main components of LEO.LEO's optimal exposure time was 12 h.Under this condition,LEO showed high anti-inflammatory activity.LLEO and HLEO had some differences on the oxidative stress markers and inflammatory factors in LPS-induced RAW 264.7 cells.There were no significant differences between LLEO and HLEO on NO secretion,SOD enzyme activities and IL-6 secretion in LPS-induced RAW 264.7 cells.HLEO was significantly better than the LLEO in reducing ROS level,improving CAT enzyme activities and inhibiting TNF-α secretion(P＜0.01).LLEO was significantly better than the HLEO in reducing MDA content(P＜0.01).The above results showed that the anti-inflammatory activity of LEO was related to its action time,compositions and content.关键词
薰衣草精油/分子蒸馏/气相色谱-质谱联用/氧化应激/抗炎活性Key words
lavender essential oil/molecular distillation/gas chromatography-mass spectrometry(GC-MS)/oxidative stress/anti-inflammatory activity分类
轻工纺织引用本文复制引用
王倩,刘菲,杨素珍,郭凤娇,哈米提江·阿力木江,吴华,魏梦雅..薰衣草精油的精制分离与抗炎活性研究[J].中国食品添加剂,2024,35(10):108-117,10.基金项目
山东省企业技术创新项目(202250101132) （202250101132）
