中国食品添加剂2024，Vol.35Issue(10)：148-155,8.DOI:10.19804/j.issn1006-2513.2024.10.018
白馕对阿司匹林致胃溃疡小鼠的保护作用研究
Research on the protective effect of white Nang on aspirin-induced gastric ulcer in mice
摘要
Abstract
In order to explore the protective effect of white Nang on gastric ulcer in mice,the study measured the contents of superoxide dismutase(SOD),catalase(CAT),glutathione peroxidase(GSH-Px),myeloperoxidase(MPO),transforming growth factor α(TGF-α),epidermal growth factor(EGF),interleukin-1β(IL-1β),interleukin-6(IL-6),and tumor necrosis factor α(TNF-α)in mouse serum.Histopathological changes in gastric tissues were observed using HE staining,and the protective effect of white Nang on gastric ulcer mice was explored based on the NF-κB protein pathway.The results revealed that white Nang could increase the levels of antioxidants(SOD,CAT,GSH-Px)and growth factor(TGF-α)in mice bodies,and reduced the levels of inflammatory factors(IL-1β,IL-6,TNF-α)in mice serum.The pathological results showed that the structure of the gastric mucosa of the mice in the white Nang group was relatively intact with fewer abnormal morphological changes.Therefore,white Nang could increase the levels of antioxidants and epidermal growth factors in mice,reduce the levels of inflammatory factors,and thus play a role in protecting the stomach.关键词
白馕/阿司匹林/胃溃疡/抗氧化/炎症因子Key words
white Nang/aspirin/gastric ulcer/antioxidant/inflammatory factors分类
轻工纺织引用本文复制引用
康洁,尼格尔热依·亚迪卡尔,冯作山,金沐柏..白馕对阿司匹林致胃溃疡小鼠的保护作用研究[J].中国食品添加剂,2024,35(10):148-155,8.基金项目
自治区重点研发计划项目(2021B02001-2) （2021B02001-2）
