急性心肌梗死合并心力衰竭患者检测PCT、NT-proBNP的意义OA
Significance of Detecting PCT and NT-proBNP in Patients with Acute Myocardial Infarction Complicated with Heart Failure
目的 探讨降钙素原(PCT)、氨基末端脑钠肽前体(NT-proBNP)指标在急性心肌梗死(AMI)合并心力衰竭(HF)患者中的变化及意义.方法 选取 2022 年 5 月至 2023 年 5 月郑州四六〇医院收治的 68 例AMI合并HF患者作为试验组,另选择同期在本院接受治疗的 60 例AMI患者作为对照组.统计两组患者基线资料[收缩压(SBP)、舒张压(DBP)、总胆固醇(TC)、三酰甘油(TG)、高密度蛋白胆固醇(HDL-C)/低密度蛋白胆固醇(LDL-C)、白细胞计数(WBC)],检测血清PCT、NT-proBNP以及心功能指标.比较两组患者各项基线资料,比较试验组患者不同心功能分级血清学相关指标,分析血清PCT、NT-proBNP水平与心功能指标的相关性.结果 试验组患者血清PCT、NT-proBNP、左室舒张末期内径(LVEDD)、左房舒张末期前后径(LAED)水平均高于对照组,左室射血分数(LVEF)水平低于对照组,差异均有统计学意义(P＜0.05);两组患者SBP、DBP、心率、TC、TG、HDL-C、LDL-C、WBC水平比较,差异无统计学意义(P＞0.05);随着心功能分级提高,患者血清PCT、NT-proBNP水平逐渐上升,差异均有统计学意义(P＜0.05);血清PCT、NT-proBNP与LVEDD、LAED呈正相关(r=0.432、0.557、0.597、0.783,P＜0.05),而与LVEF水平均呈负相关(r=-0.400、-0.422,P＜0.05).结论 AMI合并HF患者血清PCT、NT-proBNP水平异常上升,且不同心功能分级上述指标差异显著,血清PCT、NT-proBNP与LVEDD、LAED呈正相关,而与LVEF呈负相关,对PCT、NT-proBNP水平进行检测可用于评定AMI合并HF患者心功能.
Objective To investigate the changes and significance of procalcitonin(PCT)and N-terminal pro-brain natriuretic peptide(NT-proBNP)levels in patients with acute myocardial infarction(AMI)complicated with heart failure(HF).Methods A total of 68 patients with AMI complicated with HF admitted to Zhengzhou 460 Hospital from May 2022 to May 2023 were selected as the experimental group,and 60 AMI patients treated in the same period were selected as the control group.Baseline data of the two groups[systolic blood pressure(SBP),diastolic blood pressure(DBP),total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C)/low-density lipoprotein cholesterol(LDL-C),white blood cell count(WBC)]were collected.Serum PCT,NT-proBNP,and cardiac function indicators were measured.The baseline data of the two groups were compared,and the serological indicators of patients with different cardiac function grades in the experimental group were compared.The correlation between serum PCT,NT-proBNP levels,and cardiac function indicators was analyzed.Results The levels of serum PCT,NT-proBNP,left ventricular end-diastolic diameter(LVEDD),and left atrial end-diastolic diameter(LAED)in the experimental group were higher than those in the control group,while the level of left ventricular ejection fraction(LVEF)was lower than that in the control group,with statistically significant differences(P＜0.05).There were no statistically significant differences in SBP,DBP,heart rate,TC,TG,HDL-C,LDL-C,and WBC levels between the two groups(P＞0.05).With the increase in cardiac function grade,the levels of serum PCT and NT-proBNP gradually increased,with statistically significant differences(P＜0.05).Serum PCT and NT-proBNP levels were positively correlated with LVEDD and LAED(r=0.432,0.557,0.597,0.783,P＜0.05),and negatively correlated with LVEF levels(r=-0.400,-0.422,P＜0.05).Conclusion The levels of serum PCT and NT-proBNP in patients with AMI complicated with HF are abnormally elevated,and the differences in these indicators are significant among different cardiac function grades.Serum PCT and NT-proBNP levels are positively correlated with LVEDD and LAED,and negatively correlated with LVEF.Detecting PCT and NT-proBNP levels can be used to assess the cardiac function of patients with AMI complicated with HF.
杨杰
郑州四六〇医院 医学检验科,河南 郑州 450052
临床医学
急性心肌梗死心力衰竭降钙素原氨基末端脑钠肽前体心功能相关性
acute myocardial infarctionheart failureprocalcitoninn-terminal pro-brain natriuretic peptidecardiac functioncorrelation
《临床研究》 2024 (010)
132-135 / 4
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