中国中医药信息杂志2024，Vol.31Issue(10)：135-141,7.DOI:10.19879/j.cnki.1005-5304.202405134
基于指纹图谱和量值传递关系评价姜石颗粒关键生产工艺
Evaluation on Key Production Process of Jiangshi Granules Based on Fingerprint and Quantity-Value Transfer Relationship
摘要
Abstract
Objective To evaluate the key production process of Jiangshi Granules based on the new mode of combining fingerprint and quantity-value transfer relationship.Methods The fingerprints of Jiangshi Granules extract,extractum and granules were established by HPLC.The common peak transfer number of the fingerprint,the calculation of multi-component content transfer rate,and the paste rate were set as indicators to analyze the quantity and mass transfer law in the production process.The rationality of the preparation process design of Jiangshi Granules was evaluated.Results The fingerprints of 10 batches of Jiangshi Granules extract,extractum and granules were established.17 common peaks were calibrated and 8 peaks were identified.They were respectively tangshenoside I,liquiritin,lobetyolin,isoliquiritin apioside,isoliquiritin,liquiritigenin,glycyrrhizic acid,atractylenolide Ⅲ;the average transfer rates of 8 components from decoction pieces to extract were 29.42%,51.26%,23.81%,34.45%,28.29%,30.22%,42.67%,26.10%;the average transfer rates of extract to extractum were 50.05%,60.04%,51.04%,50.27%,47.60%,52.44%,53.44%,44.97%;the average transfer rates of extractum to granules were 64.83%,78.74%,70.16%,66.56%,70.62%,69.59%,76.97%,66.43%.Conclusion The established fingerprint of Jiangshi Granules extract,extractum and granules is stable and reliable,which emphasizes the integrity of the research process of TCM preparations and provides a basis for the quality control of Jiangshi Granules in the production process.关键词
姜石颗粒/指纹图谱/生产工艺/含量测定/转移率/量值传递Key words
Jiangshi Granules/fingerprint/production process/content determination/transport rate/value dissemination分类
医药卫生引用本文复制引用
张红伟,党文飞,周晶晶,周洁,靳子明,窦霞..基于指纹图谱和量值传递关系评价姜石颗粒关键生产工艺[J].中国中医药信息杂志,2024,31(10):135-141,7.基金项目
国家自然科学基金(82360944) （82360944）
甘肃省科技厅科技重大专项-2022年中医药产业创新联合体项目(22ZD6FA021-4) （22ZD6FA021-4）
兰州市城关区科学技术局课题(2021-2-9) （2021-2-9）
甘肃省中医药科研重点课题(GZKP-2022-23) （GZKP-2022-23）
甘肃中医药大学附属医院院内创新基金项目(gzfy-2020-15) （gzfy-2020-15）
