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基于药性理论探讨中医药辨治无瘤康复阶段肺癌的组方用药规律OA

Discussion on the prescription and medication rule of Chinese medicine in treating lung cancer at the stage of non-tumor rehabilitation based on the theory of drug properties

中文摘要英文摘要

目的 运用中药药性理论分析中医药辨治无瘤康复阶段肺癌的组方用药规律.方法 基于门诊病历系统,筛选、整理出2018年1月1日至2020年12月31日期间在浙江中医药大学附属第二医院就诊的无瘤康复阶段肺癌患者的基本信息及相关处方,对药物按药名、药性、药味、归经、功效分类分别进行统计分析.结果 数据挖掘纳入中药处方460首,涉及中药208味,药物累计使用频次为9158次.药性以寒、温、平为多,药味以甘、辛、苦为主,药物归经主要为肺、脾,药物功效主要是清热、补虚、化痰止咳平喘为多.处方药物中使用频次>200次的有金荞麦、薏苡仁、麦芽、浙贝母、桑白皮、石见穿、猫爪草、苦杏仁、半夏、茯苓、党参、黄芪、白术、地骨皮、泽漆,为中医药辨治无瘤康复阶段肺癌的核心处方.结论 无瘤康复阶段肺癌的核心病机为气虚痰阻,重视脏腑气机升降变化,组方用药"清补结合、肺脾同调、调气为先",达到气顺痰消、养正消积的疗效.

Objective To analyze the rule of Chinese medicine in the treatment of lung cancer at the stage of non-tumor rehabilitation by using the theory of Chinese medicine properties.Methods Based on the outpatient medical record system,the basic information and relevant prescriptions of lung cancer patients in the tumor-free rehabilitation stage treated in the Second Affiliated Hospital of Zhejiang Chinese Medical University from January 1,2018 to December 31,2020 were screened and sorted out.Software was used to classify the drugs according to drug name,property,taste,channel grouping and efficacy.Results Data mining included 460 prescriptions of traditional Chinese medicine,involving 208 kinds of traditional Chinese medicine,and the cumulative frequency of drug use was 9158 times.The drug properties were mostly cold,warm and mild,the drug flavors were mainly sweet,pungent and bitter,the main channel of drugs was lung and spleen,and the main drug effects were clearing heat,tonifying deficiency,resolving phlegm,relieving cough and relieving asthma.Among the prescription drugs,Fagopyrum tataricum,Coix seed,Malt,Fritillaria thunbergii,Cortex Mori,Herba Lithospermi,Radix Ranunculi,Semen Armeniacae Amarum,Pinellia ternata,Poria,Radix Codonopsis,Radix Astragali,Rhizoma Atractylodis Macrocephalae,Cortex Lycii and Euphorbia helioscopia are used more than 200 times,which is the core prescription of traditional Chinese medicine for treating lung cancer in the stage of non-tumor rehabilitation.Conclusion The core pathogenesis of lung cancer in tumor-free rehabilitation stage is Qi deficiency and phlegm obstruction.Attention should be paid to the changes of Qi movement of zang-fu organs.The prescription of"combination of clearing and tonifying,lung and spleen coordination,regulating Qi first"can achieve the curative effect of eliminating phlegm,nourishing Qi and eliminating accumulation,which is worthy of further research and application.

郑健

浙江中医药大学附属第二医院肿瘤科,浙江杭州 310005

中医学

肺癌中医药药性理论中医经验

Lung cancerTraditional Chinese medicineTheory of drug propertiesExperience of traditional Chinese medicine

《中国现代医生》 2024 (026)

67-70,75 / 5

浙江中医药科技计划项目(2022ZB172);浙江省名老中医传承工作室建设项目(GZS2012013)

10.3969/j.issn.1673-9701.2024.26.016

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