Th17/Treg细胞在前列腺疾病中的作用研究进展OA北大核心CSTPCD
Advances in studies of Th17/Treg cells in prostatic disease
初始CD4+T细胞在免疫效应的启动和维持中起着关键作用,在细胞因子和共刺激分子的作用下可分化为Th1、Th2、Treg和Th17等细胞.近年来越来越多证据显示,Th17和Treg细胞在免疫稳定、自身免疫性疾病和肿瘤中发挥着重要作用.慢性前列腺炎/慢性盆腔疼痛综合征(CP/CPPS)是发病率最高的前列腺炎类型,占90%～95%,并与良性前列腺增生和前列腺癌的疾病进展有着密不可分的关系.前列腺良性疾病和前列腺癌在免疫微环境上有诸多相似之处,故本综述以Th17和Treg细胞为视角,总结近年来关于Th17/Treg细胞及相关细胞因子在前列腺疾病中的作用研究进展.
Näive CD4+T cells play a key role in the initiation and maintenance of immune response.In the effect of cytokines and costimulatory molecules,they differentiate into Th1,Th2,Treg and Th17.Increasing evidences indicated that Th17 and Treg cells produce a significant effect on immune stability,autoimmune disease and cancer.Chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS)is the most common type of prostatitis,accounting for 90%～95%,which is closely correlated with the progression of be-nign prostatic hyperplasia and prostate cancer.Benign and malignant diseases of the prostate share much similarity in immune microen-vironment.Thus,this review summarizs the latest research progress on the mechanism of Th17/Treg cells in prostatic disease.
李佳蔚;孟佳林;梁朝朝
安徽医科大学第一附属医院泌尿外科,合肥 230022
临床医学
Th17细胞Treg细胞前列腺炎前列腺癌
Th17 cellTreg cellProstatitisProstate cancer
《中国免疫学杂志》 2024 (009)
1981-1985 / 5
国家自然科学基金(82200860,81870519,82170787);安徽省高校自然科学研究重点项目(2022AH051133).
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