从"肾虚血瘀"论治多系统萎缩OACSTPCD

Multiple system atrophy is a chronic and sporadic neurodegenerative disease. Traditional Chinese Medicine (TCM) considers its core pathogenesis to be rooted in deficiency of the liver,spleen,and kidney,with qi,blood,and fluid transportation and transformation imbalance as secondary characteristics. Clinical approaches often focus on treating liver and kidney deficiency,spleen and kidney deficiency,and the mutual obstruction of phlegm and blood stasis. Kidney deficiency and blood stasis are central pathogenic factors in multiple system atrophy. Kidney deficiency persists throughout the disease course and is crucial for treatment. Chronic progression of the disease involves blood stasis as both a pathological manifestation and a causative factor. As a chronic progressive disease,multiple system atrophy consistently presents patterns of deficiency and excess. Clinical treatment strategies emphasize addressing both symptoms and underlying causes,specifically through kidney supplementation and blood circulation promotion. Liuwei Dihuang Decoction (Six Ingredients Rehmannia Decoction) strengthens the kidneys and consolidates the foundation,while Siwu Decoction (Four Substances Decoction) promotes blood circulation and dispels stasis,effectively improving language and limb functions in multiple system atrophy patients. This paper discusses treating multiple system atrophy through the lens of kidney deficiency and blood stasis,supported by clinical cases.