中国当代儿科杂志2024，Vol.26Issue(10)：1019-1026,8.DOI:10.7499/j.issn.1008-8830.2404116
父母围孕期吸烟和饮酒及其交互作用与子代先天性心脏病关联的病例对照研究
A case-control study on the associations of parental smoking and alcohol consumption during the periconceptional period and their interactions with risk of congenital heart disease in offspring
摘要
Abstract
Objective To explore the associations of parental smoking and alcohol consumption during the periconceptional period and their interactions with risk of congenital heart disease(CHD)in offspring.Methods The parents of children with simple CHD aged 0 to 1 year(n=683)were recruited as the case group,while the parents of healthy children aged 0 to 1 year(n=740)served as the control group.A case-control study was conducted,and a questionnaire was used to collect information on perinatal exposures.After controlling for relevant confounding factors using multivariate logistic regression analysis and propensity score matching,the associations of parental smoking and alcohol consumption during the periconceptional period and their interactions with CHD were examined,as well as the cumulative effects of smoking and drinking on CHD risk.Results Maternal active smoking(OR=2.91,95%CI:1.60-5.30),passive smoking(OR=1.94,95%CI:1.56-2.42),and alcohol consumption(OR=2.59,95%CI:1.89-3.54),as well as paternal smoking(OR=1.52;95%CI:1.22-1.90)and drinking(OR=1.48,95%CI:1.19-1.84),were associated with an increased risk of CHD in offspring.There was no interaction between parental smoking and drinking behaviors during the periconceptional period concerning the risk of CHD in offspring(P>0.05).The more parents'smoking and drinking behaviors during the perinatal pregnancy,the higher the risk of CHD in their offspring(OR=1.50,95%CI:1.36-1.65).Conclusions Parental smoking and alcohol consumption during the periconceptional period are associated with the occurrence of CHD in offspring,and there is a cumulative effect on CHD risk,suggesting that reducing tobacco and alcohol exposure during the periconceptional period may lower the incidence of CHD.关键词
先天性心脏病/吸烟/饮酒/交互作用/病例对照研究/子代Key words
Congenital heart disease/Smoking/Alcohol consumption/Interaction/Case-control study/Offspring引用本文复制引用
李柳萱,罗曼君,阮霄睿,刘涵君,唐嘉鹏,杨贵红,秦家碧..父母围孕期吸烟和饮酒及其交互作用与子代先天性心脏病关联的病例对照研究[J].中国当代儿科杂志,2024,26(10):1019-1026,8.基金项目
国家自然科学基金项目(81803313、82073653) （81803313、82073653）
湖南省杰出青年基金项目(2022JJ1087). （2022JJ1087）
