食品科学2024，Vol.45Issue(24)：282-292,11.DOI:10.7506/spkx1002-6630-20240507-026
6-姜酚与6-姜烯酚改善肠道紧密连接损伤作用研究进展
Research Progress on Alleviatory Effects of 6-Gingerol and 6-Shogaol on Intestine Tight Junction Damage
摘要
Abstract
The intestinal barrier plays a key role in preventing harmful substance invasions and maintaining intestinal homeostasis,with tight junction proteins being essential for maintaining the integrity of the intestinal barrier.This review summarizes the structural composition of the intestinal barrier,the role of tight junction in maintaining intestinal physiological functions,with an emphasis on the potential application value of the major phenolic components in ginger,6-gingerol and 6-shogaol,for alleviating tight junction damage.Through comprehensive analysis of clinical research and experimental results in recent years,it is found that 6-gingerol and 6-shogaol can improve the expression levels of tight junction-related proteins and maintain the integrity and biofunction of the intestinal barrier by inhibiting inflammation,oxidative stress and apoptosis as well as regulating the composition of intestinal microbiota.This paper provides a theoretical basis and insights for understanding the mechanisms of action of ginger phenolic compounds in regulating health and for expanding their application scopes.关键词
6-姜酚/6-姜烯酚/紧密连接/肠道屏障/肠道损伤Key words
6-gingerol/6-shogaol/tight junction/intestinal barrier/intestinal injury分类
轻工业引用本文复制引用
李宇,欧阳芳欣,张贺,王文宇,董婧潇,李大鹏,李锋..6-姜酚与6-姜烯酚改善肠道紧密连接损伤作用研究进展[J].食品科学,2024,45(24):282-292,11.基金项目
国家自然科学基金面上项目(32372332) （32372332）
山东省自然科学基金项目(ZR2022MC004) （ZR2022MC004）
山东省重点研究发展计划项目(2021TZXD007 （）
2023TZXD070) （）
