食品与发酵工业2024，Vol.50Issue(24)：411-418,8.DOI:10.13995/j.cnki.11-1802/ts.039065
藤茶抗高尿酸血症的机制及进展
Mechanisms and research advancements of therapeutic activity of Ampelopsis grossedentata for hyperuricemia
范光河 1翟梓皓 1刘佳欣 1黄卫东 1战吉宬 1游义琳1
作者信息
- 1. 中国农业大学食品科学与营养工程学院,北京,100083
- 折叠
摘要
Abstract
Hyp eruricemia(HUA)is a prevalent metabolic disorder that can precipitate gout along with other severe complications.Ampelopsis grossedentata,a traditional medicinal plant,has long been utilized in traditional Chinese medicine to treat HUA and its related ailments.This review seeks to unravel the operational pathways of Ampelopsis grossedentata in mitigating HUA,spotlighting research mile-stones achieved to date.Initially,the article reviews the pathophysiology of HUA,focusing primarily on abnormalities in purine metabolism and uric acid excretion.An overview of current medications for the treatment of HUA,their pharmacological effects,and side effects is then provided.Then the discussion extends to assimilate findings from investigations on Ampelopsis grossedentata and its active components,indicating their roles in curtailing uric acid production,facilitating its expulsion,and fostering antioxidant and anti-inflammatory actions.Additionally,the review explores the potential mechanisms by which Ampelopsis grossedentata combats HUA,suggesting its involvement in regulating gut homeostasis and insulin resistance.Conclusively,while Ampelopsis grossedentata emerges as a formidable natural candidate for HUA management,it beckons a thorough clinical and experimental inquiry to affirm its therapeutic promise and carve its niche in clini-cal practice.关键词
高尿酸血症/藤茶/降尿酸/活性物质/机制Key words
hyperuricemia/Ampelopsis grossedentata/uric acid reduction/bioactive compounds/mechanism引用本文复制引用
范光河,翟梓皓,刘佳欣,黄卫东,战吉宬,游义琳..藤茶抗高尿酸血症的机制及进展[J].食品与发酵工业,2024,50(24):411-418,8.
