中国食物与营养2024，Vol.30Issue(11)：65-69,5.
岩藻多糖在胃肠道疾病中的应用研究进展
Research Progress on the Application of Fucoidan in Gastrointestinal Diseases
摘要
Abstract
[Objective]To investigate the biological activity of fucoidan and its effects on gastrointestinal diseases to provide scientific support for the research and development of functional food,health products and drugs with low toxic side effects for the prevention and adjuvant treatment of gastrointestinal diseases.[Method]Relevant literature was retrieved and summarized from domestic and international databases using keywords such as fucoidan,sulfated fucans,alginate,gastric mucosal protection,gut microbiota regulation,Helicobacter pylori,and nanoparticles.[Result]Fucoidan has the ability to prevent Helicobacter pylori from adhering to the gastric mucosa,reduce the formation of Helicobacter pylori biofilms,and inhibit the invasion and infection of Helicobacter pylori. It serves as a novel preparation for eradicating Helicobacter pylori,protecting the gastric mucosa,and assisting in the treatment of gastric diseases. The protective effects of fucoidan on the gastrointestinal tract are achieved through the repair of the physicochemical barrier of the gastrointestinal tract,enhance-ment of immune barrier functions,and regulation of the microbial barrier.[Conclusion]Fucoidan plays a protective,modulator and im-mune role in gastrointestinal diseases,and can be used as a dietary supplement for patients with gastric and intestinal cancer to help patients alleviate the side effects of treatment and control the outcome of slowing down the development of diseases.关键词
岩藻多糖/胃肠道疾病/幽门螺杆菌/纳米颗粒Key words
fucoidan/gastrointestinal disease/Helicobacter pylori/nanoparticle引用本文复制引用
尚伟华,刘剑英,王发合,邱霞..岩藻多糖在胃肠道疾病中的应用研究进展[J].中国食物与营养,2024,30(11):65-69,5.基金项目
青岛市医药卫生科研计划项目(项目编号:WJZD229) （项目编号:WJZD229）
青岛市科技计划园区培育计划项目(项目编号23-1-5-yqpy-9-qy) （项目编号23-1-5-yqpy-9-qy）
海藻活性物质国家重点实验室开放基金(项目编号:SKL—BMSG-2022-07). （项目编号:SKL—BMSG-2022-07）
