Ameliorative effect of walnut oil against cognitive impairment in alzheimers type dementia in rodentOA
Walnut oil(WO),known for abundant polyunsaturated fatty acids and an array of bioactive substances such as tocopherols,phytosterols,squalene,melatonin,and polyphenols,which is endowed with numerous health advantages.The primary objective of this research was to ascertain the impact of WO on cognitive deficits in learning and memory impairment mice caused by scopolamine(SCOP).The Morris water maze and the step-down avoidance test were utilized to assess the memory and learning capabilities.WO notably counteracted the detrimental effects of SCOP on learning and memory in the Morris water maze,as indicated by a reduction in escape latency and swimming distance.Likewise,WO administration led to a notably reduced number of errors in training trial and an increased latency in testing trial when compared to the SCOP group in the step-down avoidance test.Moreover,WO activated the cholinergic system of the brain by upregulating choline acetyltransferase activity and reducing acetylcholinesterase activity.These results suggest that WO has the potential to protect against memory decline in mice,offering a promising strategy for the prevention of memory-related disorders.
Congcong Ma;Li Zhang;Lei Wang;Qingde Huang;Qianchun Deng;Fenghong Huang;Jiqu Xu;
Department of Nutriology,Oil Crops Research Institute,Chinese Academy of Agricultural Sciences,Wuhan 430062,PR China Hubei Key Laboratory of Lipid Chemistry and Nutrition,Oil Crops Research Institute,Chinese Academy of Agricultural Sciences,Wuhan 430062,PR ChinaAcademy of Nutrition and Health,Hubei Province Key Laboratory of Occupational Hazard,Identification and Control,School of Public Health,Wuhan University of Science and Technology,Wuhan 430065,PR China Department of Neurology,Hubei Provincial Hospital of Integrated Chinese&Western Medicine,No.11,Lingjiaohu Road,Wuhan 430015,PR China
临床医学
Walnut oilScopolamineMemoryMorris water mazeStep-down avoidance testCholinergic system
《Oil Crop Science》 2024 (004)
P.234-239 / 6
supported by the Key Technology R&D Program of Shandong Province(2023TZXD069);the National Natural Science Foundation of China(NSFC-U21A20274);the innovation group project of Hubei Province(2023AFA042);the Earmarked Fund for China Agriculture Research System(CARS-14);by Agricultural Science and Technology Innovation Project of Chinese Academy of Agricultural Sciences(CAAS-ASTIP-2016-OCRI).
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