食品科学2025，Vol.46Issue(2)：260-267,8.DOI:10.7506/spkx1002-6630-20240610-060
短链脂肪酸介导的肠骨轴在骨代谢中的研究进展
Research Progress in Short-Chain Fatty Acid Modulation of the Gut-Bone Axis in Bone Metabolism
摘要
Abstract
As global aging intensifies,the incidence of age-related bone metabolic disorders,such as osteoporosis,continues to climb.Seeking safe and effective therapeutic interventions is of utmost importance.The modulation of bone metabolism by the gut microbiota and their metabolites has emerged as a focal area of research.Short-chain fatty acids(SCFAs),including acetic,propionic,and butyric acids,exert regulatory effects on bone formation and resorption through the gut-bone axis.Furthermore,SCFAs play positive roles in maintaining bone homeostasis and contribute to the alleviation of inflammatory bone loss.This review synthesizes the current knowledge about the mechanism by which SCFAs regulate bone metabolic homeostasis via endocrine pathways,immune modulation,and enhanced nutrient absorption,hoping to provide a scientific foundation for the prevention and treatment of metabolic bone diseases in the elderly.关键词
肠-骨轴/短链脂肪酸/肠道微生物/骨代谢/骨质疏松症Key words
gut-bone axis/short-chain fatty acids/intestinal microbes/bone metabolism/osteoporosis分类
轻工纺织引用本文复制引用
张萱,杨雪,李新科,孟璐,王加启,郑楠..短链脂肪酸介导的肠骨轴在骨代谢中的研究进展[J].食品科学,2025,46(2):260-267,8.基金项目
"十四五"国家重点研发计划重点专项(2022YFD1600104) （2022YFD1600104）
中国农业科学院科技创新工程项目(ASTIP-IAS12) （ASTIP-IAS12）
现代农业产业技术体系建设专项(CARS36) （CARS36）
