食品科学2025，Vol.46Issue(2)：317-326,10.DOI:10.7506/spkx1002-6630-20231113-100
乳铁蛋白减轻肠道功能障碍的研究进展
Research Progress in Lactoferrin's Role in Alleviating Intestinal Barrier Dysfunction
李懿 1任鑫鑫 1王勤 2贺晓云1
作者信息
- 1. 中国农业大学食品科学与营养工程学院,北京 100083
- 2. 中国农业大学动物科学技术学院,北京 100083
- 折叠
摘要
Abstract
The intestinal barrier plays a crucial role in maintaining homeostasis in the body.When the intestinal mucosa is damaged,the tight junctions between intestinal cells are disrupted,and the intestinal flora becomes imbalanced,a variety of diseases can arise.Natural active proteins are pivotal in the repair of the intestinal barrier.Lactoferrin,a glycoprotein abundant in mammalian milk,exhibits a range of biological functions such as antioxidant,anti-inflammatory and antibacterial functions.Numerous studies have shown that lactoferrin elevates the levels of intestinal tight junction proteins,promotes the growth and development of intestinal cells,down-regulates the expression of inflammatory factors,regulates the immune response and intestinal microbial diversity,and contributes to the maintenance of intestinal barrier homeostasis.In this paper,a review on the alleviation of intestinal barrier dysfunction by lactoferrin is conducted,aiming to gain a better understanding of the mechanisms underlying lactoferrin's role in alleviating intestinal injury and to provide insights for the development of lactoferrin-based interventions in intestinal diseases.关键词
乳铁蛋白/肠道屏障/生理活性/肠道微生物Key words
lactoferrin/intestinal barrier/physiological activity/gut microorganisms分类
轻工业引用本文复制引用
李懿,任鑫鑫,王勤,贺晓云..乳铁蛋白减轻肠道功能障碍的研究进展[J].食品科学,2025,46(2):317-326,10.
