乳铁蛋白减轻肠道功能障碍的研究进展OA北大核心

The intestinal barrier plays a crucial role in maintaining homeostasis in the body.When the intestinal mucosa is damaged,the tight junctions between intestinal cells are disrupted,and the intestinal flora becomes imbalanced,a variety of diseases can arise.Natural active proteins are pivotal in the repair of the intestinal barrier.Lactoferrin,a glycoprotein abundant in mammalian milk,exhibits a range of biological functions such as antioxidant,anti-inflammatory and antibacterial functions.Numerous studies have shown that lactoferrin elevates the levels of intestinal tight junction proteins,promotes the growth and development of intestinal cells,down-regulates the expression of inflammatory factors,regulates the immune response and intestinal microbial diversity,and contributes to the maintenance of intestinal barrier homeostasis.In this paper,a review on the alleviation of intestinal barrier dysfunction by lactoferrin is conducted,aiming to gain a better understanding of the mechanisms underlying lactoferrin's role in alleviating intestinal injury and to provide insights for the development of lactoferrin-based interventions in intestinal diseases.