食品工业科技2025，Vol.46Issue(2)：358-366,9.DOI:10.13386/j.issn1002-0306.2024020037
杨树桑黄多糖对糖尿病大鼠的降血糖效果及心肌保护作用
Hypoglycemic Effects and Myocardial Protection of Sanghuangporus vaninii Polysaccharide on Diabetes Rats
摘要
Abstract
To examine the hypoglycemic effects and myocardial protection of Sanghuangporus vaninii polysaccharide(SP)in T2DM rats,these effects were assessed in rats fed a high glucose and high fat diet combined with streptozotocin(STZ).The rats were randomly assigned to one of the following six groups:the diabetes mellitus(DM),metformin(MET),low-,medium-,and high-dose SP(SPL,SPM,and SPH),and control(CN)groups.Following 4 weeks of continuous intervention by gavage,the weights and multiple physiological and biochemical indicators of rats were measured and recorded,and performed pathological observations of the pancreatic and myocardial tissues of rats.Results revealed that SP at all assessed doses could reduce weight loss in T2DM rats compared to the DM group,significantly reduce fasting blood glucose and serum insulin levels,and improve glucose tolerance(P＜0.01 or P＜0.05).With an increase in the dosage of SP,serum total cholesterol(TC),triglyceride(TG),and low density lipoprotein cholesterol(LDL-C)levels in the SP-fed rats reduced(P＜0.01 or P＜0.05),whereas no significant changes in high-density lipoprotein cholesterol(HDL-C).Furthermore,there was a significant reduction in lactate dehydrogenase(LDH)activity(P＜0.01),an upregulation of total superoxide dismutase(SOD)and catalase(CAT)activities(P＜0.01 or P＜0.05),and a significant reduction in malondialdehyde(MDA)content(P＜0.01).Additionally,the SPM and SPH treatments reduced the levels of interleukin-1β(IL-1β)and interleukin-6(IL-6)in rat myocardial tissues.HE staining revealed a significant increase in the number of pancreatic islet cells in SP group rats than in the DM group rats,and the cells were more complete.Compared with the DM group,the myocardial tissue showed uniform cell gaps and reduced vacuolization after SP intervention,with the SPH group exhibiting the most significant improvement.In summary,SP can protect the structure of pancreatic and cardiac tissues,regulate blood sugar levels,reduce blood lipid contents,reduce insulin resistance,and have anti-diabetic effects in T2DM rats.关键词
桑黄多糖/2型糖尿病/胰腺/心肌保护Key words
Sanghuangporus vaninii polysaccharide/type 2 diabetes/pancreas/myocardial protection分类
轻工纺织引用本文复制引用
常悦,吴悦,郭建峰,赵尉园,陆源添,刘迪..杨树桑黄多糖对糖尿病大鼠的降血糖效果及心肌保护作用[J].食品工业科技,2025,46(2):358-366,9.基金项目
国家重点研发项目(2017YFD0300104) （2017YFD0300104）
中韩国际农业技术合作项目(延大横向[2019]第19号). （延大横向[2019]第19号）
