食品科学2025，Vol.46Issue(3)：257-266,10.DOI:10.7506/spkx1002-6630-20240718-191
溶酶体的代谢调节及调控肉嫩化机制的研究进展
Research Progress on Metabolic Regulation of Lysosomes and Their Regulatory Mechanism on Meat Tenderness
摘要
Abstract
Tenderness is one of the most important indicators to judge meat quality,and it is also the most important sensory index for consumers to choose meat.Postmortem muscle undergoes complex biochemical processes,and apoptosis is considered to be a key biochemical pathway to regulate postmortem muscle tenderization.Lysosomes are rich in cathepsins,and a large amount of cathepsins are released after lysosomal membrane permeabilization,which activates the caspase cascade through the intrinsic lysosomal-mitochondrial pathway,triggering apoptosis and consequently accelerating postmortem muscle tenderization.This article introduces the action mechanism and metabolic processes of lysosomes and elaborates the activation pathways of lysosomal membrane permeabilization through reactive oxygen species(ROS),sphingosine,B-cell lymphoma-2(Bcl-2)and p53 proteins.Furthermore,it explores the pathway for the involvement of lysosomes in apoptosis,and summarizes the regulatory mechanism of lysosomes on muscle tenderization from the perspectives of the release of cathepsins and Ca2+,caspase activation and iron-induced oxidative stress.We hope that this review can provide a theoretical reference for improving meat tenderness.关键词
溶酶体/膜通透化/组织蛋白酶/细胞凋亡/溶酶体铁/嫩度Key words
lysosome/membrane permeabilization/cathepsin/apoptosis/lysosomal iron/tenderness分类
轻工纺织引用本文复制引用
董玉珊,杜瑞,苏日娜,姚丽丽,杜雪蓉,李晨龙,吴俊琴,侯艳茹,罗玉龙..溶酶体的代谢调节及调控肉嫩化机制的研究进展[J].食品科学,2025,46(3):257-266,10.基金项目
国家自然科学基金青年科学基金项目(32202135) （32202135）
国家自然科学基金地区科学基金项目(32460612) （32460612）
宁夏自治区重点研发计划项目(2024BBF02023) （2024BBF02023）
宁夏青年科技人才托举工程项目 （）
