现代食品科技2025，Vol.41Issue(1)：37-46,10.DOI:10.13982/j.mfst.1673-9078.2025.1.0035
鹿皮胶氨基酸成分及其药食同源组方的免疫增强作用
Amino acid Composition of deer skin Gelatin and the Immune-enhancing Effects of its Drug-food Homologous Prescription
摘要
Abstract
Different deer skin gelatin samples of amino acid compositions were investigated and its drug-food homologous prescription was used to study immunomodulatory effects on immune-suppressed mice.Amino acid composition was comprehensively analyzed using an amino acid analyzer.Various parameters,including body weight,immune organ indices,immune factor levels,delayed-type hypersensitivity,serum hemolysin,carbon clearance assay,peritoneal macrophage phagocytosis of chicken red blood cells,and jejunal histopathological changes,were observed in different mouse groups.The results revealed that deer skin gelatin contains 17 amino acids,with a total content ranging from 68.47 to 69.82 g/100 g.Glycine had the highest content(17～18 g/100 g),while cysteine had the lowest(0.15～0.3 g/100 g),with sample 3 scoring the highest.Different doses of deer skin gelatin(0.7,1.4,and 2.8 g/kg)in traditional medicine formulations significantly increased the thymus index(2.36,2.47,and 2.51 mg/g),spleen index(5.43,5.84,and 5.94 mg/g),carbon particle clearance(5.22,5.30,and 5.66),serum hemolysin levels(47.87,50.6,and 53.4),macrophage phagocytosis index(0.34,0.35,and 0.36),phagocytosis rate(43.20%,44.57%,and 44.87%),and immunological factors IgA(133.40,134.34,and 146.81 pg/mL),IgG(121.83,129.83,and 133.58 pg/mL),IgM(200.44,204.58,and 214.4 pg/mL),IFN-γ(109.55,110,and 113.75 pg/mL),TNF-α(173.80,176.79,179.14 pg/mL),and IL-4(164.26,172.04,and 208.85 pg/mL).Meanwhile,ear swelling degree significantly decreased(5.91,5.46,and 5.55 mg),and ileal mucosal barrier damage was improved.In conclusion,deer skin gelatin possesses rich amino acid content,and its traditional medicine formulations exhibit immunomodulatory effects,which provides new ideas for the development of healthy food.关键词
鹿皮胶/氨基酸/药食同源/免疫功能Key words
deer skin gelatin/amino acids/medicine and food are homologous/immune function引用本文复制引用
靳梓微,张荣华,赵春娇,张腾月,宋岩,李银清..鹿皮胶氨基酸成分及其药食同源组方的免疫增强作用[J].现代食品科技,2025,41(1):37-46,10.基金项目
吉林省科技发展项目(20210204007YY) （20210204007YY）
