乳业科学与技术2025，Vol.48Issue(1)：30-40,11.DOI:10.7506/rykxyjs1671-5187-20240914-086
多光谱法和分子模拟技术在蛋白质与活性成分相互作用分析中的应用研究进展
Progress in the Application of Multispectral and Molecular Simulation Techniques to the Analysis of Protein-Active Ingredient Interaction
摘要
Abstract
Protein is an important nutrient in the food system,and active ingredients(such as polyphenols,flavonoids,and terpenes)have a variety of physiological effects because of their unique chemical structures,such as antioxidant,antitumor,and chronic disease-preventive effects.They form complexes through covalent or noncovalent interactions,thus changing their functional structure,nutritional properties,and bioavailability.In this review,we summarize the application of multispectral methods,including ultraviolet-visible(UV-vis)absorption,fluorescence,Fourier transform infrared(FTIR),circular dichroism(CD)spectra,and molecular simulation techniques(molecular docking and molecular dynamics simulation)in the study of protein-active ingredient interaction.The principles,features,and examples of these techniques in the study of the interaction between protein and active ingredients are briefly described.This review also focuses on the application of molecular simulation in delivering active ingredients,regulating food flavor,and monitoring food quality based on protein-active ingredient systems,hoping to provide scientific reference for further study of the interaction between protein and active ingredients.关键词
蛋白质/活性成分/光谱方法/分子模拟技术/相互作用机制Key words
protein/active ingredients/spectral techniques/molecular simulation/interaction mechanism分类
轻工纺织引用本文复制引用
贾利蓉,贾志龙,杨敏,文鹏程,张卫兵,乔海军..多光谱法和分子模拟技术在蛋白质与活性成分相互作用分析中的应用研究进展[J].乳业科学与技术,2025,48(1):30-40,11.基金项目
甘肃省自然科学基金重点项目(24JRRA634) （24JRRA634）
国家自然科学基金地区科学基金项目(32460576 （）
21864002) （）
甘肃省高校青年博士支持项目(2024QB-062) （2024QB-062）
中央引导地方科技发展资金项目(23ZYQP0001) （23ZYQP0001）
