食品工业科技2025，Vol.46Issue(7)：385-395,11.DOI:10.13386/j.issn1002-0306.2024040031
化学法降解岩藻聚糖制备低分子量岩藻聚糖和岩藻寡糖的研究进展
Research Progress on Chemical Degradation of Fucoidan for Preparation of Low-molecular Weight Fucoidan and Fucooligosaccharide
摘要
Abstract
Fucoidans are sulphated polysaccharides that are primarily derived from brown algae and marine invertebrates.Fucoidans generally have complex structural characteristics,which contribute to their various pharmacological activities including anti-tumor,anti-atherosclerotic,anti-inflammatory,antioxidant,anti-coagulant and lipid-lowering effects.However,fucoidans are difficult to be absorbed due to their large molecular weight.Comparatively,low-molecular weight fucoidans and fucoidan-derived oligosaccharides are easier to be absorbed,and these molecules are demonstrated to have equal or even better bioactivities compared with the original fucoidans.Therefore,degradation of fucoidan has become a research hotspot in recent years.Currently,chemical degradation,physical degradation,and biodegradation have been used for degradation of fucoidans.However,biodegradation primarily relies on special enzymes that are hard to be prepared and commercialized at present.It is worth noting that chemical degradation is characterized by a simple preparation process,low cost,and easy for transformation and application.During the past decades,significant progress has been made in this field.This article reviews the advances in chemical degradation of fucoidans by focusing on the degradation conditions and mechanisms of actions.This article provides information valuable for chemists that are interested in preparation of fucoidan-derived oligosaccharides and low-molecular weight fucoidans,for pharmacologists that are interested in investigating the bioactivities of fucoidans with different molecular weight,and for manufacturers that are interested in applying low-molecular weight fucoidans and fucooligosaccharides as functional foods and/or drug additives.关键词
岩藻聚糖/酸降解/自由基降解/低分子量岩藻聚糖/岩藻寡糖Key words
fucoidan/acid degradation/free radical degradation/low-molecular weight fucoidan/fucoidan oligosaccharide分类
轻工纺织引用本文复制引用
刘海迪,马冬月,汲晨锋,辛国松,李文兰,郭守东..化学法降解岩藻聚糖制备低分子量岩藻聚糖和岩藻寡糖的研究进展[J].食品工业科技,2025,46(7):385-395,11.基金项目
国家自然科学基金(82070469) （82070469）
中央支持地方高校改革发展资金人才培养项目. （）
