食品科学2025，Vol.46Issue(7)：172-182,11.DOI:10.7506/spkx1002-6630-20240910-083
两歧双歧杆菌CCFM1167及组合菌株对洛哌丁胺诱导便秘的缓解作用
Alleviating Effects of Bifidobacterium bifidum CCFM1167 and Its Combinations with Other Probiotics on Loperamide-Induced Constipation
摘要
Abstract
In this study,in order to evaluate the alleviating effect of Bifidobacterium bifidum on constipation,a mouse model of constipation was established by gavaging mice with loperamide.After four weeks of intervention with B.bifidum CCFM1167 alone or in combination with B.longum subsp.longum CCFM1113 or Lacticaseibacillus rhamnosus CCFM1060,constipation-related indicators,intestinal barrier function,inflammatory cytokines,and gut microbiota were evaluated.The results demonstrated that both single and combined strains alleviated constipation,but the underlying mechanisms were different.CCFM1167 alleviated constipation primarily by promoting intestinal mucus secretion.In contrast,both probiotic combinations relieved constipation by repairing the intestinal mechanical and immune barriers.This study elucidates the potential mechanisms of action of combined probiotics in alleviating constipation,providing a basis for the formulation of probiotic combinations for constipation relief.关键词
便秘/复配益生菌/胃肠调节递质/肠道机械屏障/结肠组织损伤/肠道菌群Key words
constipation/probiotic combinations/gastrointestinal regulatory peptides/intestinal mechanical barrier/colonic tissue injury/gut microbiota分类
轻工纺织引用本文复制引用
许福春,王一,涂秋榕,张娟,王琳琳,王鸿超,喻喜华..两歧双歧杆菌CCFM1167及组合菌株对洛哌丁胺诱导便秘的缓解作用[J].食品科学,2025,46(7):172-182,11.基金项目
国家自然科学基金面上项目(32472348) （32472348）
