食品科学2025，Vol.46Issue(7)：183-194,12.DOI:10.7506/spkx1002-6630-20240504-005
聚己二酸/对苯二甲酸丁二醇酯-改性淀粉材料迁移物的体外肾毒性
In Vitro Nephrotoxicity of Migrants from Polybutylene adipate-co-terephthalate-Modified Starch Composite Material
摘要
Abstract
To investigate the nephrotoxicity of polybutylene adipate-co-terephthalate(PBAT)-modified starch composite material,substances migrating to different food simulants(4%acetic acid,10%ethanol,and 95%ethanol)from the composite material were prepared and evaluated for its toxicity in human renal proximal tubule epithelial(HK-2)cells by analyzing the adenosine monophosphate-activated protein kinase(AMPK)/mammalian target of rapamycin(mTOR)pathway and the expression levels of silent information regulator sirtuin 1(SIRT1),peroxisome proliferators-activated receptor γ coactivator-l alpha(PGC-1α),nuclear respiratory factor-1(NRF1)and recombinant transcription factor A(TFAM).The results showed that the migrants increased the expression level of kidney injury molecule-1(KIM-1),elevated inflammatory factor levels and decreased antioxidant factor levels in HK-2 cells.The migrants upregulated the p-AMPK/AMPK ratio in HK-2 cells,and downregulated the p-mTOR/mTOR ratio as well as the expression levels of SIRT1,PGC-1α,NRF1,and TFAM.In summary,the migrants from the composite material could induce oxidative stress and inflammation in HK-2 cells.Furthermore,it might lead to mitochondrial dysfunction through the AMPK signaling pathway,resulting in kidney damage and posing a potential threat to human health.关键词
聚己二酸/对苯二甲酸丁二醇酯-改性淀粉共混材料/迁移物/肾损伤/氧化应激和炎症Key words
polybutylene adipate-co-terephthalat-modified starch composite material/migration/kidney injury/oxidative stress and inflammation分类
轻工纺织引用本文复制引用
王旭锴,陈聪颖,让一峰,肖雪蔓,李银焕,王俊明,柳春红..聚己二酸/对苯二甲酸丁二醇酯-改性淀粉材料迁移物的体外肾毒性[J].食品科学,2025,46(7):183-194,12.基金项目
广东省重点领域研发计划项目(2019B020210002) （2019B020210002）
