食品科学2025，Vol.46Issue(7)：309-317,9.DOI:10.7506/spkx1002-6630-20240806-051
氟吡菌胺及其代谢物、霜霉威在3种绿叶蔬菜上的残留行为及膳食风险评估
Residual Behavior and Dietary Risk Assessment of Fluopicolide,Its Metabolite and Propamocard on Three Leafy Vegetables
摘要
Abstract
Purpose:Field trials were conducted in 10 provinces to assess the safety of applying fluopicolide+propamocarb hydrochloride to three leafy vegetables,Lactuca sativa,pakchoi and crown daisy.The residual dynamics of fluopicolide,its metabolite 2,6-dichlorobenzamide and propamocard on the vegetables was investigated,and dietary risk assessment of the three compounds was conducted.Methods:Samples were extracted with acetonitrile and purified by solid phase extraction(SPE),and the analytes were detected by ultra-high performance liquid chromatography-tandem mass spectrometry(GC-MS/MS).Results:The average recovery rates of fluopicolide,2,6-dichlorobenzamide and propamocard were 82%-109%,74%-103%and 76%-115%,with relative standard deviation(RSD)of 2%-13%,1%-13%and 2%-8%in the three leafy vegetables at three spiked levels(0.01,0.5,30 and 70 mg/kg),respectively,and the limit of quantification was 0.01 mg/kg for all three compounds.The dissipation of fluopicolide and propamocard in L.sativa,pakchoi and crown daisy followed a first-order kinetics model.The degradation half-lives of fluopicolide on the three leafy vegetables was 3.0-3.4,2.2-5.4,and 6.3-6.5 days,respectively,while those of propamocard were 3.3-5.5,1.8-5.1,and 7.1 days,respectively.Fluopicolide+propamocarb hydrochloride(687.5 g/L)was sprayed three times on three leafy vegetables with a spraying interval of 7 days and safety interval of 5 days at the recommended dosage of 1 125 mL/hm2.The final residues of fluopicolide,2,6-dichlorobenzamide and propamocard were as follows:1.03-4.21,0.01-0.03,and 6.71-15.10 mg/kg in L.sativa;0.66-2.90,0.01-0.02,and 3.49-13.80 mg/kg in pakchoi;1.30-8.93,0.01-0.04,and 5.18-29.80 mg/kg in crown daisy,respectively.All residue levels were lower than the maximum residue limit(MRL).The risk assessment results showed that the acute and chronic dietary risk of fluopicolide,2,6-dichlorobenzamide and propamocard were all lower than 100%for populations of different ages and genders,indicating an acceptable level.Conclusion:This study provides the technical basis for understanding the dissipation pattern and dietary risk assessment of fluopicolide,2,6-dichlorobenzamide and propamocard on L.sativa,pakchoi and crown daisy and offers scientific guidance for safe application of fluopicolide and propamocard to leafy vegetables.关键词
氟吡菌胺及代谢物/霜霉威/绿叶蔬菜/残留/膳食风险评估Key words
fluopicolide and its metabolite/propamocard/leafy vegetables/residue/dietary risk assessment分类
轻工业引用本文复制引用
李新新,黄兰淇,陈秀,温广月,张颂函,赵莉..氟吡菌胺及其代谢物、霜霉威在3种绿叶蔬菜上的残留行为及膳食风险评估[J].食品科学,2025,46(7):309-317,9.基金项目
上海市特色小宗作物安全绿色用药技术研究与示范项目(沪农科推字(2022)第2-4号) （沪农科推字(2022）
