食品科学2025，Vol.46Issue(9)：165-176,12.DOI:10.7506/spkx1002-6630-20240923-175
狄氏副拟杆菌对2型糖尿病引起认知障碍的改善作用
Ameliorative Effect of Parabacteroides distaxsonis on Cognitive Impairment Caused by Type 2 Diabetes Mellitus
摘要
Abstract
Objective:To investigate the ameliorative effect and mechanism of Parabacteroides distasonis on cognitive impairment caused by type 2 diabetes mellitus(T2DM).Methods:Ten-week-old db/db mice were administered with P.distasonis(1×109 CFU/mL)by gavage for 5 weeks.During this period,the body mass and insulin resistance of all mice were monitored.Behavioral tests were conducted to evaluate changes in spatial memory,recognition memory,and working memory capacity.Furthermore,serum levels of insulin,total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C),and triglycerides(TG)were measured,along with morphological and inflammatory changes in liver,brain,and colon tissues.Additionally,changes in serum bile acids and the mRNA expression of genes associated with bile acid metabolism were examined.Results:Intervention with P.distasonis effectively regulated blood glucose homeostasis and insulin resistance in db/db mice.It reduced the mass of adipose tissue,decreased hepatic fat accumulation,and lowered serum concentrations of TC,LDL-C and TG.The intervention restored colonic morphology,protected intestinal barrier integrity,and reduced intestinal inflammation.It also promoted bile acid production and activated bile acid metabolism-related signaling pathways.Meanwhile,it suppressed cerebral neuroinflammation and oxidative stress,repaired neuronal damage,and significantly alleviated cognitive impairment.Conclusion:P.distasonis intervention can lower blood glucose,alleviate insulin resistance,and mitigate glucose and lipid metabolic disorders as well as cognitive dysfunction induced by T2DM,showing potential as a new generation of probiotics for diabetic management.关键词
狄氏副拟杆菌/2型糖尿病/降血糖/认知障碍/胆汁酸Key words
Parabacteroides distasonis/type 2 diabetes mellitus/blood glucose reduction/cognitive impairment/bile acids分类
轻工纺织引用本文复制引用
杜玥,赵中娜,刘学波..狄氏副拟杆菌对2型糖尿病引起认知障碍的改善作用[J].食品科学,2025,46(9):165-176,12.基金项目
陕西省科技计划重点产业创新链项目(2024SF-ZDCYL-03-23) （2024SF-ZDCYL-03-23）
